Human IGF-II (Media Grade)

$300.00$1,280.00

The Eagle Biosciences Human Insulin-Like Growth Factor-II (Media Grade) is for research use only and not to be used for diagnostic procedures.

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Human IGF-II (Media Grade)

The Eagle Bioscience’s Human IGF-II (Media Grade) is for research use only and not to be used for diagnostic procedures.


Product Specifications

Source:

 Produced in E.coli. 

Description:

Human insulin-like growth factor-II (IGF-II) is a single chain 67 amino acid polypeptide that shares structural homology with insulin and human IGF-I. IGF-II plays a critical role in embryonic and foetal development via autocrine, paracrine and endocrine mechanisms. It is a mitogen and also has effects on cell migration and differentiation. IGF-II binds to the type I IGF receptor and the IGF-II/cation-independent mannose-6-phosphate receptor. Its actions are probably mediated through inducing signal transduction via one or both of these receptors. IGF-II also binds to each of the six IGF binding proteins (IGFBPs). This binding also regulates the biological function of IGF-II. IGF-II is highly conserved across species which suggests an important role for the peptide. Human IGF-II is present in high concentrations in normal adult human serum, although the function of this is unknown. IGF-II is also implicated in the pathophysiology of cancer, diabetes and obesity. 

  • Quantity: 100 µg, 1 mg
  • Molecular Weight: 7469 ± 2 Daltons
  • N-terminal Sequence: Analysis of 5 residues
  • Biological Activity: Proliferation of Chinese hamster ovary (CHO) cells  (EC50 ≤ 150 ng/ml)
  • Appearance: White powder freeze-dried from 0.1M acetic acid and stored under nitrogen at a slight vacuum.
  • Endotoxin: ≤ 0.1 EU/μg
  • Storage: At least 2 years at 2-8°C (as a freeze dried product).
  • Reconstitution: Dissolve in 0.1 ml phosphate buffered saline and allow to stand at room temperature for 10 minutes. Dilute in a buffer suitable for the desired application.

Related Products

Human Des [1-6] IGF-II
Human [Arg6] IGF-II
Di-Biotinyl Human IGF-II


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Package Inserts

Product Manual


Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

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