Human Alpha Synuclein S129A Mutant Monomers
Human Alpha Synuclein S129A Mutant Monomers are For Research Use Only
Size: 100 ug
Species: Human
Expression System: E. coli
Buffer: 1X PBS pH 7.4
Storage Temperature: -80ºC
Alternative Names: Alpha synuclein protein, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson’s disease familial 1 Protein, Alpha Synuclein S129A
Research Areas:: Alzheimer’s Disease, Neurodegeneration, Neuroscience, Parkinson’s Disease, Synuclein, Tangles & Tau, Multiple System Atrophy
Product manufactured in Canada by StressMarq.
Scientific Background
Elevated levels of phosphoserine 129 (pS129) on alpha-synuclein has long been considered a hallmark of Parkinson’s disease and other synucleinopathies, where up to 90% of alpha-synuclein deposition in Lewy Bodies contains pS129, compared to ≤4% in normal brains (reviewed in [1]). Further, pS129 was recently shown to function as a physiological regulator of neuronal activity (2). Alpha-synuclein S129A monomers and fibrils cannot be phosphorylated at position 129, and therefore can be utilized to study phospho-S129-independent biology and pathology. Further, this material can be used to confirm induction of endogenous pS129 pathology in disease models.
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