Alpha Synuclein TNG (A53T-S87N-N103G) Mutant Pre-formed Fibrils


The Alpha Synuclein TNG (A53T-S87N-N103G) Mutant Pre-formed Fibrils are for research use only and not to be used in diagnostic procedures. Contact us for bulk pricing.

SKU: SPR-504B Categories: ,

Alpha Synuclein TNG (A53T-S87N-N103G) Mutant Pre-formed Fibrils

Alpha Synuclein TNG (A53T-S87N-N103G) Mutant Pre-formed Fibrils are For Research Use Only

Size: 100 ug
Species: Human
Expression System: E. coli
Buffer: 1X PBS pH 7.4
Storage Temperature: -80ºC
Alternative Names: Alpha synuclein protein, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson’s disease familial 1 Protein, Alpha Synuclein TNG
Research Areas:: Alzheimer’s Disease, Neurodegeneration, Neuroscience, Parkinson’s Disease, Synuclein, Tangles & Tau, Multiple System Atrophy

Product manufactured in Canada by StressMarq.

Scientific Background

Human alpha synuclein TNG mutant (HuTNG) is a triple mutant containing Ala53 mutated to the equivalent mouse residue Thr53, Ser87 mutated to the equivalent mouse residue Asn87, and Asn103 mutated to the equivalent mouse residue Gly103, effectively making it a human-mouse chimeric protein. Despite sequence differences at only seven residues, or 5% of the total 140 amino acids, the aggregation rate of wild-type mouse α-syn (MsWT) is faster than wild-type human α-syn (HuWT) in vitro. In wild-type mouse models, MsWT fibrils are more efficient than HuWT fibrils at inducing endogenous mouse α-syn pathology. A53T or S87N substitutions in human α-syn substantially accelerate fibrilization rates in vitro. Chimeric HuTNG fibrils show enhanced induction of α-syn pathology greater than both HuWT and MsWT fibrils after single unilateral injection into the dorsal striatum in mice (4). Therefore, HuTNG is a good construct for inducing robust endogenous α-syn seeding and pathology in wild-type mice.

Related Products

Active Human Recombinant Gamma Synuclein Protein Preformed Fibrils (Type 1)
Active Human Recombinant Truncated Tau Fragment (AA297-391) (dGAE) Protein Monomer

Package Inserts

Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations