Tau441 (2N4R) P301S Mutant Protein Pre-formed Fibrils
The Tau441 (2N4R) P301S Mutant Protein Pre-formed Fibrils is For Research Use Only
Expression System: Baculovirus
Buffer: PBS pH 7.4
Storage Temperature: -80ºC
Alternative Names: Tau PFFs, Tau PFF, Tau protein Pre-formed Fibrils, Tau aggregates, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, mouse Tau protein, P301S mutant Tau, 2N4R Tau, Tau441
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Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65. It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907. Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils. There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 that impairs the ability of tau to assemble microtubules.