Monoclonal Mouse Anti-Human p63 Antibody

$160.00$570.00

The Eagle Biosciences Monoclonal Mouse Anti-Human p63 antibody is intended for qualified laboratories to qualitatively identify by light microscopy, the presence of associated antigens in formalin-fixed, paraffin-embedded (FFPE) tissue sections using immunohistochemistry test methods. The Mouse Monoclonal Anti-Human p63 Antibody is for research use only and not to be used for diagnostic procedures.

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SKU: IHC063 Categories: ,

Monoclonal Mouse Anti-Human p63 Antibody

The Monoclonal Mouse Anti-Human p63 Antibody is For Research Use Only

Clone: IHC063
Source: Mouse Monoclonal
Positive Control: Normal Prostate
Localization: Nuclear


Background

p63 is a tumor suppressor protein that is very similar to p53 in structure and function, while being homologous to p73. p63 is important in development and differentiation, and has been identified as a useful marker for distinguishing between lung squamous cell carcinomas and adenocarcinomas. Anti-p63 is also used to differentiate between benign and malignant prostate and breast lesions, due to its labeling of the nuclei of myoepithelial cells in both tissue types.

Antibody Principle

Visualization of the antigen present in tissue sections is accomplished in a multi-step immunohistochemical staining process, in conjunction with a horseradish peroxidase (HRP) or alkaline phosphatase (AP) linked detection system. The process involves the addition of the stated antibody (primary antibody) to a tissue slide, followed by a secondary antibody (linked to an enzyme complex) which specifically binds to the primary antibody. A chromogenic substrate is then added which reacts with the enzyme complex, resulting in a colorimetric reaction at the site of the antigen. Results are interpreted using a light microscope. .


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