Monoclonal Mouse Anti-Human p16 INK4A Antibody

$150.00$560.00

The Eagle Biosciences Monoclonal Mouse Anti-Human p16INK4A antibody is intended for qualified laboratories to qualitatively identify by light microscopy, the presence of associated antigens in formalin-fixed, paraffin-embedded (FFPE) tissue sections using immunohistochemistry test methods. The Monoclonal Mouse Anti-Human p16INK4A Antibody is for research use only and not to be used for diagnostic procedures.

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SKU: IHC116 Categories: ,

Monoclonal Mouse Anti-Human p16 INK4A Antibody

The Monoclonal Mouse Anti-Human p16 INK4A Antibody is For Research Use Only

Clone: IHC116
Source: Mouse Monoclonal
Positive Control: Normal Tonsil; Colon Cancer; Cervical Cancer
Localization: Cytoplasmic, Nuclear


Background

The p16 (p16 INK4A) protein is a cyclin-dependent kinase (CDK) inhibitor that plays an important regulatory role in the cell cycle. By controlling the transition between the G1 and S phases through regulation of retinoblastoma protein, p16 decelerates cellular differentiation and therefore acts as a tumor suppressor, making it the key marker in several human cancers including head and neck cancer, perianal lesions, melanomas, gliomas, lymphomas, and some types of leukemia. p16 is also clinically indicated in carcinomas of the esophagus, pancreas, lung, biliary tract, liver, colon, and urinary bladder.

Antibody Principle

Visualization of the antigen present in tissue sections is accomplished in a multi-step immunohistochemical staining process, in conjunction with a horseradish peroxidase (HRP) or alkaline phosphatase (AP) linked detection system. The process involves the addition of the stated antibody (primary antibody) to a tissue slide, followed by a secondary antibody (linked to an enzyme complex) which specifically binds to the primary antibody. A chromogenic substrate is then added which reacts with the enzyme complex, resulting in a colorimetric reaction at the site of the antigen. Results are interpreted using a light microscope.


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