Monoclonal Rabbit Anti-Human PD-L1 Antibody

$70.00$250.00

The Eagle Biosciences Monoclonal Rabbit Anti-Human PD-L1 Antibody is intended for qualified laboratories to qualitatively identify by light microscopy, the presence of associated antigens in formalin-fixed, paraffin-embedded (FFPE) tissue sections using immunohistochemistry test methods. The Eagle Biosciences Monoclonal Rabbit Anti-Human PD-L1 is for research use only and not to be used for diagnostic procedures.

SKU: IHC411 Categories: ,

Monoclonal Rabbit Anti-Human PD-L1 Antibody

The Monoclonal Rabbit Anti-Human PD-L1 Antibody is For Research Use Only

Clone: IHC411
Source: Rabbit Monoclonal
Positive Control: Tonsil, Lung Adencarcinoma
Localization: Membranous/Cytoplastic


Background

Programmed Death-Ligand 1 (PD-L1), CD274, or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumour cells resistant to lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade
the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumour aggressiveness and risk of death. When considered in adjunct with CD8+ tumour-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small-cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.

Antibody Principle

Visualization of the antigen present in tissue sections is accomplished in a multi-step immunohistochemical staining process, in conjunction with a horseradish peroxidase (HRP) or alkaline phosphatase (AP) linked detection system. The process involves the addition of the stated antibody (primary antibody) to a tissue slide, followed by a secondary antibody (linked to an enzyme complex) which specifically binds to the primary antibody. A chromogenic substrate is then added which reacts with the enzyme complex, resulting in a colorimetric reaction at the site of the antigen. Results are interpreted using a light microscope.


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Documents

Product Manual


 

Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

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