Monoclonal Rabbit Anti-Human PD-L1 Antibody

$70.00$250.00

The Eagle Biosciences Monoclonal Rabbit Anti-Human PD-L1 Antibody is intended for qualified laboratories to qualitatively identify by light microscopy, the presence of associated antigens in formalin-fixed, paraffin-embedded (FFPE) tissue sections using immunohistochemistry test methods. The Eagle Biosciences Monoclonal Rabbit Anti-Human PD-L1 is for research use only and not to be used for diagnostic procedures.

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SKU: IHC411 Categories: ,

Monoclonal Rabbit Anti-Human PD-L1 Antibody

The Monoclonal Rabbit Anti-Human PD-L1 Antibody is For Research Use Only

Clone: IHC411
Source: Rabbit Monoclonal
Positive Control: Tonsil, Lung Adencarcinoma
Localization: Membranous/Cytoplastic


Background

Programmed Death-Ligand 1 (PD-L1), CD274, or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumour cells resistant to lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade
the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumour aggressiveness and risk of death. When considered in adjunct with CD8+ tumour-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small-cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.

Antibody Principle

Visualization of the antigen present in tissue sections is accomplished in a multi-step immunohistochemical staining process, in conjunction with a horseradish peroxidase (HRP) or alkaline phosphatase (AP) linked detection system. The process involves the addition of the stated antibody (primary antibody) to a tissue slide, followed by a secondary antibody (linked to an enzyme complex) which specifically binds to the primary antibody. A chromogenic substrate is then added which reacts with the enzyme complex, resulting in a colorimetric reaction at the site of the antigen. Results are interpreted using a light microscope.


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