Human TGF-β3

$170.00$320.00

The Eagle Biosciences Human TGF-β3 is for research use only and not to be used for diagnostic procedures.

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Human TGF-β3

The Eagle Bioscience’s Human TGF-β3 is for research use only and not to be used for diagnostic procedures.


Product Specifications

Source:

Produced in E.coli using a patented expression system.

Description:

TGF-β3 (transforming growth factor beta 3) is one of three closely related mammalian members of the large TGF-β super family that share a characteristic cysteine-knot structure. TGF-β1, -β2 and -β3 are highly pleiotropic cytokines that regulate immune function, proliferation and epithelial mesenchymal transition. Each TGF-β isoform has some non-redundant functions. So mice with a targeted deletion of TGF-β3 show defects in palatogenesis and pulmonary development. Human TGF-β3 cDNA encodes a 412 amino acid precursor that contains a 20 amino acid signal peptide and a 392 amino acid precursor. A furin-like convertase processes the precursor to generate an N terminal 220 amino acid latency associated peptide and a C terminal 112 amino acid mature TGF-β3. Mature human TGF-β3 shows 100%, 99% and 98% identity with mouse/dog/horse, rat and pig TGF-β3, respectively.

  • Purity: >95 % (as determined by HPLC analysis)
  • Quantity: 20 µg, 100 µg
  • Molecular Weight: 25,427 daltons- confirmed by Mass Spectrometry
  • N-terminal sequence analysis: Analysis of 5 residues
  • Biological Activity: Inhibition of proliferation in mink lung epithelial cells (Mv1Lu) (IC50 < 0.75 ng/ml)
  • Endotoxin (LAL): <0.1 EU/ug
  • Storage/Stability: At least 2 years at 2-4°C (lyophilized)
  • Appearance: White powder freeze-dried with mannitol.

Related Products

Mouse TGF-beta 3 ELISA Kit
Mouse TGF-beta 2 ELISA Kit
Rat IGF-II

Documents

Product Manual


Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations