Human LR3 IGF-I (Receptor Grade)

$170.00$320.00

The Eagle Bioscience’s Human LR3 IGF-I (Receptor Grade) is for research use only and not to be used for diagnostics procedures.

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Human LR3 IGF-I (Receptor Grade)

The Eagle Bioscience’s Human LR3 IGF-I (Receptor Grade) is for research use only and not to be used for diagnostic procedures.


Product Specifications

Source:

Produced in E.coli. 

Description:

Human LR3 insulin-like Growth Factor-I (LR3IGF-I) is an 83 amino acid analogue of IGF-I comprising the complete human IGF-I sequence with the substitution of an Arginine for the Glutamine at position 3, plus a 13 amino acid extension peptide at the N-terminus. 

Human LR3IGF-I is more potent than IGF-I in vitro and in vivo. This increased potency is due to reduced binding of LR3IGF-I to most of the IGF binding proteins which modify the biological actions of IGF-I. Human LR3IGF-I binds to the type 1 IGF receptor with similar affinity to wild type IGF-I. 

LR3IGF-I was developed by GroPep specifically for supplementation of mammalian cell culture to support the survival and proliferation of cells. It is engineered to have a higher biological potency than native IGF-I or IGF-II and has several advantages over recombinant insulin. Supplementation of cell cultures with LR3IGF-I at a much lower concentration results in equivalent or better productivity than supplementation with standard concentrations of insulin. LR3IGF-I is better able to stimulate the type I IGF receptor and thus induce a higher level of activation of intracellular signalling molecules which are responsible for promoting cell survival by inhibition of apoptosis. 

Receptor grade LR3IGF-I is a high quality research reagent for use in studies on cell growth, IGF receptors and IGF binding proteins. 

  • Purity: >95 %
  • Quantity: 20 µg, 100 µg
  • Molecular Weight: 9110.6±2 daltons
  • N terminal sequence: Analysis of 18 residues
  • Biological Activity: Proliferation of Chinese Hamster Ovary (CHO) cells  (ED50 < 350 ng/ml)
  • Endotoxin (LAL): <0.1 EU/ug
  • Storage/Stability: At least 2 years at 2-8°C (lyophilized)
  • Appearance: White powder
  • State: Freeze-dried from 0.1M acetic acid and stored under nitrogen at a slight vacuum.

Related Products

Human LR3 IGF-I ELISA Assay Kit
Human LR3 IGF-I (Media Grade)
IGF-1 ELISA Assay Kit


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Documents

Product Manual


Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations