Human IGFBP-6

$410.00

The Eagle Bioscience’s Human Insulin-Like Growth Factor Binding Protein-6 (IGFBP-6) is for research use only and not to be used for diagnostic procedures.

SKU: BP6BU100 Categories: , ,

Human IGFBP-6

The Eagle Bioscience’s Human IGFBP-6 is for research use only and not to be used for diagnostic procedures.


Product Specifications

Source:

Expressed in a mammalian cell expression system and purified by a series of chromatography steps.

Description:

Human Insulin-like growth factor binding protein-6 (IGFBP-6) is a 213 amino acid glycosylated protein which is a member of a family of six circulating proteins which bind IGF-I and IGF-II with high affinity and modulate their metabolic and mitogenic effects. IGFBP-6 is unique among IGFBPs for its IGF-II binding specificity since it binds IGF-II with a 20-70 fold higher affinity than IGF-I. IGFBP-6 inhibits growth of a number of IGF-II-dependent cancers, including rhabdomyosarcoma, neuroblastoma and colon cancer. Although the major action of IGFBP-6 appears to be inhibition of IGF-II actions, a number of studies suggest that it may also have IGF-independent actions.

  • Purity: >95 % (by HPLC)
  • Quantity: 100 µg
  • Molecular Weight: Glycosylated IGFBP-6 is 28-30 kDa by SDS PAGE. Single band determined by ligand blotting.
  • Endotoxin (LAL): <0.1 EU/ µg
  • Storage/Stability: At least 2 years at 2-4°C (lyophilized)
  • Appearance: White Powder
  • State: Dried from 0.1 M acetic acid under dry nitrogen at a slight vacuum.

Related Products

IGFBP-6 ELISA Assay Kit
Biotinylated IGFBP-6 Recombinant Protein
Biotinylated IGFBP-2 Recombinant Protein


If you have any specific questions about this product or would like to hear more about our other offerings, contact us here.

Package Inserts


Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations