The Eagle Bioscience’s Human IGFBP-6 is for research use only and not to be used for diagnostic procedures.
Expressed in a mammalian cell expression system and purified by a series of chromatography steps.
Human Insulin-like growth factor binding protein-6 (IGFBP-6) is a 213 amino acid glycosylated protein which is a member of a family of six circulating proteins which bind IGF-I and IGF-II with high affinity and modulate their metabolic and mitogenic effects. IGFBP-6 is unique among IGFBPs for its IGF-II binding specificity since it binds IGF-II with a 20-70 fold higher affinity than IGF-I. IGFBP-6 inhibits growth of a number of IGF-II-dependent cancers, including rhabdomyosarcoma, neuroblastoma and colon cancer. Although the major action of IGFBP-6 appears to be inhibition of IGF-II actions, a number of studies suggest that it may also have IGF-independent actions.
- Purity: >95 % (by HPLC)
- Quantity: 100 µg
- Molecular Weight: Glycosylated IGFBP-6 is 28-30 kDa by SDS PAGE. Single band determined by ligand blotting.
- Endotoxin (LAL): <0.1 EU/ µg
- Storage/Stability: At least 2 years at 2-4°C (lyophilized)
- Appearance: White Powder
- State: Dried from 0.1 M acetic acid under dry nitrogen at a slight vacuum.
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