Human Des [1-3] IGF-I


The Eagle Bioscience’s Human Des [1-3] IGF-I is for research use only and not to be used in diagnostic procedures.

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Human Des [1-3] IGF-I

The Eagle Bioscience’s Human Des [1-3] IGF-I is for research use only and not to be used for diagnostic procedures.

Product Specifications


IGF-I is produced in E.coli using a patented expression system and the IGF-I is correctly folded and purified by several chromatography steps to yield Receptor Grade IGF-I.


Human Des [1-3] insulin-like Growth Factor-I is a 67 amino acid analogue of human IGF-I lacking the N-terminal tripeptide Gly-Pro-Glu. Human Des [1-3] IGF-I is more potent than IGF-I in vitro and in vivo. This increased potency is due to reduced binding of it to most of the IGF binding proteins which modify the biological actions of IGF-I. This product binds to the type 1 IGF receptor with similar affinity to wild type IGF-I. This is a high quality research reagent for use in studies on cell growth, IGF receptors and IGF binding proteins. 

  • Purity: >95 % (as determined by HPLC analysis)
  • Quantity: 100 µg
  • Molecular Weight: 7370±2 daltons – confirmed by Mass Spectrometry
  • N-terminal sequence analysis of recombinant product: Analysis of 5 residues
  • Biological Activity: Stimulation of protein synthesis in rat L6 myoblasts (ED50 < 10 ng/ml) IGF type 1 receptor binding assay (ED50 < 10 ng/ml) IGF binding protein assay: ED50 > 100 ng/ml)
  • Endotoxin (LAL): <0.1 EU/ug
  • Storage/Stability: At least 2 years at 2-4°C (lyophilized)
  • Appearance: White Powder
  • State: Dried from 0.1 M acetic acid under dry nitrogen at a slight vacuum (-25kPa)

Related Products

Receptor Grade IGF-I Recombinant Protein
Human Arg3 IGF-1 Biotin
Biotinylated Human Des IGF-1

Package Inserts

Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations