Human IGF-II (Receptor Grade)

$250.00$2,380.00

The Eagle Bioscience’s Human IGF-II (Receptor Grade) is for research use only and not to be used in diagnostic procedures.

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Human IGF-II (Receptor Grade)

The Eagle Bioscience’s Human IGF-II (Receptor Grade) is for research use only and not to be used for diagnostic procedures.


Product Specifications

Source:

IGF-II is produced in E.coli using a patented expression system.

Description:

Human insulin-like growth factor-II (IGF-II) is a single chain 67 amino acid polypeptide that shares structural homology with insulin and human IGF-I. IGF-II plays a critical role in embryonic and foetal development via autocrine, paracrine and endocrine mechanisms. It is a mitogen and also has effects on cell migration and differentiation. IGF-II binds to the type I IGF receptor and the IGF-II/cation-independent mannose-6-phosphate receptor. Its actions are probably mediated through inducing signal transduction via one or both of these receptors. IGF-II also binds to each of the six IGF binding proteins (IGFBPs). This binding also regulates the biological function of IGF-II. IGF-II is highly conserved across species which suggests an important role for the peptide. Human IGF-II is present in high concentrations in normal adult human serum, although the function of this is unknown. IGF-II is also implicated in the pathophysiology of cancer, diabetes and obesity. 

  • Purity: >95 % (as determined by HPLC analysis)
  • Quantity: 1 mg
  • Molecular Weight: 7469 ± 2 Daltons – confirmed by Mass Spectrometry
  • N-terminal sequence analysis of recombinant product: 5 residues >95% single sequence
  • Biological Activity: Proliferation of Chinese hamster ovary (CHO) cells (EC50 ≤ 150 ng/ml)
  • Endotoxin (LAL): <0.1 EU/ug
  • Storage/Stability: At least 2 years at 2-8°C (lyophilized)
  • Appearance: White Powder
  • State: Dried from 0.1 M acetic acid under dry nitrogen at a slight vacuum (-25kPa)

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IGF-II ELISA Assay Kit
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Package Inserts

Package Inserts


Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

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