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A recent study by Stanford University Scientists demonstrated that they could alter brain activity of rats and either wake them up or put them in an unconscious state. The study was published ineLIFE, was partially funded by the National Institutes of Health.
Scientists studied how the thalamus tunes brain activity during different states of consciousness in rats. Central thalamus plays a critical role in forebrain arousal and organized behavior. However, network-level mechanisms that link its activity to brain state remain a mystery.To investigate and explore the effects of the thalamus on the brain, they studied possible mechanisms underlying the frequency-dependent cortical inhibition, by performing recordings in zona incerta, where 10, but not 40, Hz stimulation evoked spindle-like oscillations. In other words, scientists were trying to stimulate thalamic neurons to evoke a response in the brain. Dr. Lee who performed the study suggests, the central thalamus works similar to a radio dial that tunes the brain to different states of activity or arousal.
Th results of this study did in fact demonstrate how the circuits of the brain can regulate arousal states. According to Dr. Lee,“We hope to use this knowledge to develop better treatments for brain injuries and other neurological disorders.”
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Promising New Target for the Treatment of Chronic Pain
A recent study conducted by Case Western Reserve University using Eagle Biosciences’ Transferrin (TfR) Receptor ELISA from our Oxidative Stress Assay Kit line. This assay is part of our Oxidative Stress Assay Kit Line which is a comprehensive group consisting of a numerous valuable tools for assisting scientists in fields of research such as diabetes, cancer, aging, and other similar areas of study. See the product page below for full details on the kit or view the links below to find a new publication referencing our Transferrin (TfR) Receptor ELISA (TfR)
Citation:
Anemia Among Children Exposed to Polyparasitism in Coastal Kenya
Study Summary:
Anemia represents a substantial problem for children living in areas with limited resources and significant parasite burden. The objective for this research was to evaluate the potential links between low hemoglobin and socioeconomic factors, nutritional status, hemoglobinopathy, and/or parasite infection. A cross-sectional study was performed utilizing a cohort of 254 Kenyan children of early school-age in a setting endemic for multiple chronic parasitic infections to explore mechanisms of their anemia.
Complete venous blood cell counts revealed a high prevalence of local childhood anemia (79%). EagleBio’s Transferrin (TfR) Receptor ELISA (TfR) was used to measure TfR values in serum samples.
Children in the youngest age group had the greatest odds of iron deficiency (OR: 10.0, 95% CI: 3.9, 26).Although older children aged 9–11 years had less anemia, they had more detectable malaria, Schistosoma infection, hookworm, and proportionately more non-IDA. Anemia in this setting appears multi-factorial such that chronic inflammation and iron deficiency need to be addressed together as part of integrated management of childhood anemia.
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MDA Oxidized LDL ELISA Assay Published in Obesity Research and Clinical Practice Journal
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Monthly Promotions- 40% off All Vitamin Assays
EagleBio’s Vitamin B6 HPLC Assay Kit Utilized in a Dietary and Vitamin Analysis Study in Pregnant Women
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40% Discount on EagleBio’s: Vitamin Assays
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A recent study was conducted by the University of Alberta utilizing our Vitamin B6 HPLC Assay Kit in our Vitamin Assay Kit line. The Vitamin Assay Kit line offered Eagle Biosciences provides unique and sensitive assays for measuring a variety of vitamin analytes. Researchers in the field are continually accomplishing fascinating studies and using our kits to do so! Check out the product pages for full details on the kit or view the links below to find a new publication referencing our Vitamin B6 HPLC Assay Kit.
Citation:
Dietary Intake and Status of Folate, Vitamin B12 and Vitamin B6 in Pregnant Women in Alberta
Study Summary:
A multivitamin supplement containing folic acid is recommended during pregnancy. The purpose of
this study was to determine folate, vitamin B12 and vitamin B6 status and to estimate
the contribution of food and supplements to the intake of folate, vitamin B12 and
vitamin B6 in pregnant women. Very few studies have reported vitamin B6 status, important in the etiology of Neural Tube Defects (NTD) during pregnancy. We proposed to determine plasma pyridoxal 5-phosphate concentration, a biomarker of vitamin B6 status, during pregnancy.
Eagle Biosciences’ Vitamin B6 HPLC Assay Kit was used to assess vitamin B6 status in pregnant women.
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A recent study was conducted by the University Health Science Center utilizing the Chromogranin A ELISA in our Cancer Biomarker Assay Kit Line. The Cancer Biomarker Assay Kit Line offered Eagle Biosciences provides a comprehensive array of sensitive and valuable tools to assist researchers in new emerging market segments in cancer research such as tumor marker and antitumor therapy investigation. Check out the product pages for full details on the kit or view the links below to find a new publication referencing our Chromogranin A ELISA. Our Chromogranin A ELISA is for Research Use Only.
Citation:
Hsu, C. et al “Chromogranin A levels and mortality in patients with severe sepsis.” Biomarkers: 20(3):171-176.
Study Summary:
Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis. Serum chromogranin A (CgA) levels were measured in 50 hospitalized, severely septic patients with organ failure using EageBio’s commercially available human Chromogranin A ELISA Assay Kit. The purpose of this study was to assess the association of CgA levels and mortality risk of severely septic patients.
The results of this study revealed higher CgA levels that trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01. Normal serum CgA level in healthy adults is less than 100 ng/ml. Based on these results and that overall data from this study, it was concluded that high CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.
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A year ago we discussed the quest for new types of therapy for C. difficile infections and brought to light the radical new treatment with ingestion of stool. Last year we shared the study’s objective to investigate whether delivering FMT orally through capsules designed to open upon reaching the small intestine would be just as effective as other more invasive treatments such as delivering frozen fecal material for FMT either by colonoscopy or nasogastric tube.
OpenBiome (the nonprofit stool bank and research platform sponsoring this research) has continued to build up their stool bank (consisting of paid donors’ samples) and has collaborated with clinicians, hospitals, and researchers. In the past year, they commenced a multi-center, cluster randomized study that investigates the efficacy and safety of using encapsulated stool for Fecal microbiota transplantation (FMT) in treating recurrent C. difficile. Treatment with a high dose after an initial nonresponse yielded an aggregate clinical cure rate of 94 percent… Read More
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What are Antibody-Drug Conjugates?
Antibody-drug conjugates (ADCs)are a new type
of targeted therapy for cancer treatment that offer significant promise to
oncology-related areas. ADCs are cancer
cell specific monoclonal antibodies that are conjugated with highly potent
cyotoxics via a specific linker, which deliver and release the drug directly
inside the tumor cell. The ADC’s antibody binds with a specific receptor on the
target cell’s surface. The linkage is then broken and the ADC releases a lethal
toxin into the cell. ADCs, thus have potential to significantly increase target
specificity and reduce toxicity.
Ideally, this targeted therapeutic approach attacks
diseased cells while leaving healthy ones alone. This is a strategy that could
result in more effective treatments for cancer and other diseases with fewer
toxic side effects than current traditional chemotherapies.
Why Measure Antibody-Drug Conjugates?
Measurement of circulating specific cytotoxic ADCs are extremely important for pre-clinical and clinical studies to help
discover unique, targeted, efficacious, and safer anticancer treatments. In fact, their ability to directly target and
deliver highly potent cytotoxic agent to tumor cells creates a more favorable therapeutic
window than would be achieved by the administration of free cytotoxic agent.
The antibody–drug conjugate field has made
significant progress recently due to careful optimization of several parameters
such as mAb specificity, drug potency, linker technology, and the stoichiometry
and placement of conjugated drugs. Measuring such analytes provide unique
insight and incredible value to cancer research, and
more specifically antitumor therapeutic investigation.
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Conjugate ELISA Assays
References:
1 .Alley S. et al. “Antibody–drug conjugates: targeted drug delivery for cancer.”Next Generation Therapeutics. 14(4):529-527.
2. Girish, S. et al. “Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody–drug conjugate in development for the treatment of HER2-positive cancer. Cancer Chemother Pharmacol. 2012; 69:1229–1240.
3.Ornes, S. et al. “Antibody–drug conjugates.” PNAS. 2013; 110(34): 13695.