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Eagle Biosciences’ Cardiovascular line is a full list of unique assays for the comprehensive determination of important and emerging biomarkers of cardiovascular disease.  Our Endothelin (1-21) ELISA and Big Endothelin-1 ELISA are robust and not only offer direct measurement of these analytes but also provide flexibility to run manually or in an automated system. Collectively, these assays provide a comprehensive means to accurately and easily measure the endothelin system and circulating concentrations of endothelin. 

EagleBio’s Endothelin Assays offer several key attributes  such as excellent sensitivity, use with multiple sample types, and small sample volume requirements which make these assay kits excellent tools for evolving research in cardiovascular and stress-related fields of study.

Why Measure Endothelins?

The principle actions of endothelin surround increasing blood pressure and vascular tone, thus endothelin antagonists may serve to play important roles in offsetting the negative impact endothelin has in invivo. Both Big ET and ET are strong independent predictors of survival in patients
with congestive heart failure, and identify a population with a very high risk of mortality.  

The biological role of ET extends beyond endothelins’ primary vascular and growth regulatory properties. Due to the complex nature of the endothelin system, further research may be necessary to further define these biological intricacies for the development of therapeutic agents. Robust, sensitive, and specific immunoassays could be valuable tools to assist researchers in these investigations. Read more

Key Advantages of EagleBio’s Endothelin (1-21) ELISA 

• Ultra-sensitivity – quantifies as little as 0.05 pg/ml Endothelin
• Direct measurement: measures both normal and pathological samples -no extraction of samples needed
• Versatility: provides ability to use multiple sample types in various animal species
• Serum Based Standards and Controls: provides biologically reliable data
• Lyophilized Reagents: simplifies procedure with no reagent preparation
• Flexibility: provides ability to run manually and easily with the simple procedure

EageBio offers 1 additional Standard in protein buffered matrix- can be used for spike and recovery experiments, making further standards as required for certain institutions, or for other matrices (i.e. cell culture, species).

Key Advantages of EagleBio’s Big Endothelin-1 ELISA

• Ultra-sensitivity – quantifies as little as 0.02 pmol/ml Endothelin
• Direct measurement: measures both normal and pathological samples -no extraction of samples needed
• Versatility: provides ability to use in serum and plasma
• Serum Based Standards and Controls: provides biologically reliable data
• Lyophilized Reagents: simplifies procedure with no reagent preparation
• Flexibility: provides ability to run manually and easily with the simple procedure

EagleBio’s Big Endothelin-1 ELISA is the only assay available in the market to measure big endothelin-1!

Related Kits:

Endothelin (1-21) ELISA Assay Kit

Big Endothelin-1 ELISA Assay Kit

Cardiovascular Assay Kits

Related News:

EagleBio Spotlight: Endothelin

Eagle Biosciences Introduces Endothelin 1-21 and Big Endothelin-1 ELISA Kit

Eagle Biosciences’ Catecholamine Sensitive Assays: are the most sensitive catecholamine assays worldwide. These assays offer amazing flexibility by including an extraction plate and reagent set in each kit allowing for the use of a variety of sample types (serum, plasma, tissue, and other biological samples) and numerous different species. EagleBio’s Catecholamine Assays are robust tools for assisting researchers at the forefront of neurobiology and catecholamine-related research.

Catecholamines can be used to study numerous health conditions and disease states such as:

• Tumors of the chromaffine system (pheochromocytoma, neuroblastoma, ganglio­neuroma). 
• Hypertension
• Degenerative cardiac diseases
• Schizophrenia 
• Manic-depressive psychosis

The measurement of Catecholamines is also important for studying the effectiveness of therapeutic drugs for the conditions listed above.

Dopamine Sensitive ELISA

For the quantitative and very sensitive determination of dopamine in biological samples including serum, plasma, tissue, and cell culture samples. Also appropriate for mouse/rat samples. Sample sizes as small as 20µl with detection limits to 5.9 pg/mL.

Dopamine & Noradrenaline Sensitive ELISA

For the quantitative and very sensitive determination of noradrenaline and dopamine in biological samples including serum, plasma, tissue, and cell culture samples. Sample sizes as small as 20µl with detection limits to 2.4 pg/ml for Noradrenaline and 4.9 pg/ml.

Noradrenaline Sensitive ELISA

For the quantitative and very sensitive determination of noradrenaline in biological samples including serum, plasma, tissue, and cell culture samples or even mouse/rat samples. Sample sizes as small as 20µl with detection limits to 1.0 pg/mL.

Adrenaline Sensitive ELISA

For the quantitative and very sensitive determination of adrenaline in biological samples including serum, plasma, tissue, and cell culture samples and even rodent samples. Sample sizes as small as 20µl with detection limits to 1.6 pg/mL.

Serotonin Sensitive ELISA

The Serotonin Ultrasensitive ELISA Assay Kit provides materials for the quantitative measurement of serotonin in low concentrated samples, for small sample volumes or for many different species samples.

Related News:

EagleBio’s Serotonin ELISA: A Rock Solid Assay and 5 Recent Citations you Should Not Miss

New Study Referencing EagleBio’s Serotonin ELISA Assay Kit

January 21, 2015- Eagle Biosciences Shares Some New Publications Across Multiple EagleBio Assay Kit Product Lines

July 5, 2012: Eagle Biosciences Introduces High Sensitive Catecholamine Assay Kits

Related Kits:

Adrenaline ELISA

Dopamine ELISA

Noradrenaline ELISA

Neurobiology Assay Kits

Catecholamine Assay Kits

A recent study was conducted at Medical Sciences Research Centre, Autonomous University of the State of Mexico citing EagleBio’s MDA Oxidized LDL ELISA Assay Kit, a kit designed for the quantitative determination of human MDA Oxidized LDL in serum or plasma. This assay is part of our Oxidative Stress Assay Kit Line which is a comprehensive group consisting of a numerous valuable products for assisting scientists in fields of research such as diabetes, cancer, aging, and other similar areas of study. See the product page below for full details on the kit or view the links below to find a new publication referencing our MDA Oxidized LDL ELISA Assay Kit.  

Publication:

Laguna-Camacho, Antonino. “Direct effects of fatty meals and adiposity on oxidised low-density lipoprotein.” Obesity Research & Clinical Practice 2015: 9(3): 298-300.

Study Summary:

The objective of this study was to track high-fat meals during a four week period to observe and study the effects of sustained frequency change on adipostiy and oxidized LDL. EagleBio’s MDA Oxidized LDL ELISA Assay Kit was utilized to measure Malondialdehyde (MDA)-modified Apo B in human serum.  The findings indicated that changes in frequency of consumption of high-fat eating episodes correlated directly with changes in adiposity and oxidized Low-density lipoprotein (ox-LDL). Hence the number of fatty meals consumed by people with overweight or obesity in few weeks could affect the atherogenic process.  

Related Kits:

Malondialdehyde (MDA) HPLC Assay Kit

Lipid Peroxidase Assay Kit

OLAB IgG Anti-Oxidized LDL ELISA Assay Kit

OxyStat Colorimetric Assay Kit

MutaGEL® Oxidative Stress I PCR Assay

MutaGEL® Oxidative Stress II PCR Assay

Oxidative Stress Assay Kits 

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