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Serotonin may mediate effects of infection in the womb

by Eagle Biosciences


Infection during pregnancy blunts development of the fetal brain by boosting levels of the chemical messenger serotonin, a new study suggests(1).

A wealth of data tie infection in a pregnant woman to a slightly increased risk of autism in her child. Prenatal exposure to inflammation is known to disrupt brain development and produce autism-like behaviors in mice. Read More

Source: (https://spectrumnews.org/news/serotonin)

References (used in source above):
  1. Goeden N. et al. J. Neurosci. 36, 6041-6049 (2016) PubMed

 

Related Assays:

SEROTONIN ELISA ASSAY KIT

SEROTONIN ULTRASENSITIVE ELISA ASSAY KIT

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Maryland Study: EagleBio’s IGF-1 BIOTINYLATED (BIOTIN IGF-1)

by Eagle Biosciences
Maryland Study: EagleBio’s IGF-1 BIOTINYLATED (BIOTIN IGF-1)

EagleBio_Biotin-IGF1_Cancer_Research_Study

IGF-1 BIOTINYLATED (BIOTIN IGF-1) is for Research Use Only. Not for diagnostic procedures.

 

Eagle Biosciences’ IGF-1 BIOTINYLATED (BIOTIN IGF-1 was recently utilized in a study conducted at Frederick National Laboratory for Cancer Research in Maryland. Our Biotin- R3 IGF-I is prepared by a selective biotinylation procedure and is offered in a stable and convenient lyophilized solution. Our technology permits biotinylation without loss of binding capacity to
IGFBP´s or IGF antibodies. Potential Applications: Western-ligand blotting,Western-ligand blots with biotinylated IGF-I and analogs, and ELISAs.

 

Publication:

Mammalian cell transient expression, non-affinity purification, and characterization of human recombinant IGFBP7, an IGF-1 targeting therapeutic protein

It has been well documented that insulin-like growth factor 1 (IGF-
1) plays multiple roles during cancer development. Therefore, targeted
manipulation of IGF-1 signal pathway is an attractive strategy for cancer
treatment. Insulin-like growth factor-binding protein 7 (IGFBP7), a nonIgG
protein, interacts directly with IGF-1 and VPS24. Read More

(Source:https://www.researchgate.net/publication/282944657)

Related kits:

MULTISPECIES IGF-1 ELISA

Related News:

Cancer treatment on a cellular level

October 1, 2012: Eagle Biosciences Introduces Recombinant Human Insulin, Biotin-labeled (Biotinylated Insulin)

 

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Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer

by Eagle Biosciences

Resistance to endocrine therapy is a major impediment to successful treatment of breast cancer. Preclinical and clinical evidence links resistance to antiestrogen drugs in breast cancer cells with the overexpression and/or activation of various pro-oncogenic tyrosine kinases. Disruption of circadian rhythms by night shift work or disturbed sleep-wake cycles may lead to an increased risk of breast cancer and other diseases. Moreover, light exposure at night (LEN) suppresses the nocturnal production of melatonin that inhibits breast cancer growth. Read More

Source:(https://cancerres.aacrjournals.org/content/74/15/4099)

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Write a Review for EagleBio Products and Earn a $25.00 Amazon Gift Card

by Eagle Biosciences
Write a Review for EagleBio Products and Earn a $25.00 Amazon Gift Card

Eagle Biosciences is a leading provider of immunoassays, antibodies, and proteins worldwide. We bring unique and solid life science test solutions with our Eagle developed products and products from our European partners. We strive to continually offer esoteric and innovative scientific tools that aid medical research and clinical laboratories. As the work of our customers continually evolves, our robust assay kits enable them to advance research in a variety of emerging areas of study and disciplines.

There have been several publications to date for our assays and if you are one of the many customers who has success and liked Eagle Biosciences’ products, you now have the chance to share your experience with other researchers on Biocompare.com,
and receive a $25 Amazon gift card. Learn more

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Interesting New Research: Team develops promising Zika vaccine candidates

by Eagle Biosciences


Researchers around the world have been racing to develop a vaccine for the Zika virus, and it appears that a large team of US researchers have developed two very promising candidates.

According to a report published in the journal Nature, researchers developed one potential vaccine using a Zika virus isolated in Brazil, and another candidate using a Zika virus isolated in Puerto Rico. Preclinical results showed both candidates were able to protect mice against an infection with the Zika virus by stimulating the rodents’ immune system. Furthermore, neither candidate was found to have significant side effects. Read More


Source: (https://www.redorbit.com/news/health/1113414773/promising-zika-vaccine-candidates-062816)

Categories

Herpes and Constipation: Firming Up a Loose Connection

by Eagle Biosciences

shutterstock_235683694

(Credit: Piotr Marcinski/Shutterstock) 


Constipation and an inability to empty the bladder are rare, but not unheard of, complaints from patients who acquire a genital herpes infection.

The thing is, doctors couldn’t say how these seemingly unrelated symptoms were linked to the infection. Now, a team led by Akiko Iwasaki, a professor of immunobiology at Yale University and a Howard Hughes Medical Institute investigator, has discovered a mechanism that directly ties the viral infection with gastrointestinal complications. Read More

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Recent UK Study Utilizes EagleBio’s Adrenaline and Noradrenaline ELISA

by Eagle Biosciences

A recent study by the University of Manchester in the UK used Eagle Biosciences’ Adrenaline (Epinephrine) ELISA Assay Kit and Noradrenaline (Norepinephrine) ELISA Assay Kit to measure adrenaline and noradrenaline respectively in mice.

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

It is becoming clear that intestinal microbiota play key roles in both host development and in maintaining homeostasis. Intestinal microbiota change with age and are also influenced by environmental factors such as diet, and disease (Flint et al., 2012, Wu, 2011 and Spor et al., 2011). Recent research highlights the key role of microbial communities in the large intestine in essential immune defence mechanisms and control of inflammatory responses (Abt et al., 2012 and Ganal et al., 2012). Impaired regulation of the intestinal microbiota is also known to contribute to diseases of the intestinal tract, and is linked with the development of diverse inflammatory conditions such as sepsis, metabolic disease or cancer (Ayres et al., 2012, Dupont and Dupont, 2011, Le Chatelier et al., 2013 and Yoshimoto et al., 2013). Read more

Related Kits:

Adrenaline (Epinephrine) ELISA Assay Kit

Noradrenaline (Norepinephrine) ELISA Assay Kit

BiCAT Adrenaline and Noradrenaline ELISA Assay Kit

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Comparison of a commercial ELISA (25-OH-Vitamin D Kit, Eagle Biosciences) and Liquid chromatography-mass spectrometry (LC/MS) assay to determine the serum 25-hydroxycholecalciferol in the broiler chicken.

by Eagle Biosciences

 

 

25-OH Vitamin D ELISA Assay Kit (VID31-K01)

Comparison of a commercial ELISA (25-OH-Vitamin D Kit, Eagle Biosciences®) and Liquid chromatography-mass spectrometry (LC/MS) assay to determine the serum 25-hydroxycholecalciferol in the broiler chicken.

An experiment was conducted to compare the serum 25-hydroxycholecalciferol (25-OH-D3) concentrations values in broiler chickens from two different analytical assays.This recent publication compares EagleBio’s 25-OH Vitamin D ELISA with a Liquid chromatography-mass spectrometry (LC/MS) assay. In this study, it was evident that both assays were able to detect changes in the serum 25-OH-D3 concentration during the 24-h exposure to the treatment diets. Read more

Related Kits:

VITAMIN ASSAY KITS

25-OH VITAMIN D ELISA ASSAY KIT

25-OH VITAMIN D HPLC ASSAY KIT

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EagleBio Offers New Tocilizumab ELISA Assay Kit

by Eagle Biosciences



Tocilizumab (Actemra ®) ELISA Assay Kit is for Research Use Only. Not to be used in diagnostic procedures.

A new ELISA assay kit for the quantitative determination of free Tocilizumab.   This new kit, Tocilizumab (Actemra ®) ELISA Assay Kit has recently been added to our Immunology Assay Kit line which is a complete group comprised of a unique, versatile set of products for a variety of applications, research, and fields of study surrounding overall immunological health and immunological-related disorders.

What is Tocilizumab?

The drug Tocilizumab (trade name Actemra®) is a humanized monoclonal antibody (mAb) that specifically targets both soluble interleukin-6 receptor (sIL6R) and membrane bound interleukin-6 receptor (mIL-6R) with high affinity, thereby preventing pro-inflammatory effects of IL-6.

Why Measure Tocilizumab ELISA from EagleBio?

This Tocilizumab ELISA (mAb-Based) measures the free form of Tocilizumab and the choice of specifically measuring the free form allows investigators to analyze the concentration-effect relationship.  Our assay is superior to any other assay kit in the market in terms of specificity.

Our assay offers:

  • Unique Specificity:  use of monoclonal antibodies against Tocilizumab both in the solid phase and the conjugate.
  • Fast results: incubation time- 2.25 hours
  • Automatable: suitable also for using by an automated ELISA processor.

 

 

Tocilizumab (Actemra ®) ELISA Assay Kit

Catalog number: IG-AB108