Image credit: https://www.latimes.com
“What if you could design a drug that has all the pain-relieving power of morphine but none of its dangerous or addictive side effects?
Scientists have spent years trying to do just that, and on Wednesday, they unveiled one of their most promising compounds yet — a chemical concoction they dubbed “PZM21.” ” Read More
Source: (https://www.latimes.com/science/la-sci-sn-drug-mimics-opioids-20160817-snap-story.html)
Eagle
Biosciences’ Cardiovascular Assay Kit Line is comprised of a full list of
unique assays for the comprehensive determination of important and emerging
biomarkers of cardiovascular disease. Our ADMA Fast ELISA is one of the unique assays in the this Cardiovascular Assay Kit Line that offers a variety of advantages over competing kits such as excellent
specificity, sensitivity, and excellent correlation to LC-MS/MS.
ADMA is an endogenous
molecule which can be detected in human blood and urine and it acts as an
inhibitor of nitric oxide (NO) synthesis [2]. Elevated ADMA levels indicate the presence of a variety of diseases and
health conditions. Vallance et. al decribes, “Many researchers
today agree that ADMA may play a prominent role in the pathogenesis and in the
progression of cardiovascular diseases – specifically atherosclerosis” [1]. The measurement of ADMA levels in serum or
plasma provides incredible value and insight beyond traditional risk markers in
cardiovascular research.
References:
1. Parlak, Adem et al. The effect of valsartan and nebivolol treatment on ADMA and pentraxin-3 levels in hypertensive patientsMedical Hypotheses; 2012. 79(3): 294 – 298.
2. Vallance P, Leone A, Calver A, Collier J, Moncada S. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J. Cardiovasc. Pharmacol. 1992; 20(12): S60 – S62.
Related Products:
Cardiovascular Assay Kits
ADMA ELISA Assay Kit
ADMA(Asymmetric Dimethylarginine) / Arginine ELISA Assay Kit
ADMA
Ultrasensitive ELISA Assay Kit
Homoarginine
ELISA Assay Kit
Cardiovascular
Assay Kits
Related News:
September 2015: Eagle Biosciences Introduces New Fast ADMA
ELISA Assay
EagleBio Biomarker Spotlight: ADMA
New Listing of ADMA Assay Publications
August 4, 2011: Eagle Biosciences Introduces ADMA ELISA
Product Line
“There were few studies of Zika virus (ZIKV), a
flavivirus, until this past year, when large epidemics
in the Americas were accompanied by
unexpectedly severe clinical manifestations. Infection
in pregnant women has emerged as a
major global concern because of its linkage to
congenital abnormalities including microcephaly,
spontaneous abortion, and intrauterine growth
restriction.1
In addition, ZIKV infection in other
age groups has been associated with severe neurologic
disease and the Guillain–Barré syndrome.” Read More
Source:(https://www.nejm.org/doi/full/10.1056/NEJMcibr1605445?query=genetics&)
EagleBio’s Intact FGF-21 ELISA Kit was recently cited in Boston Study:
“Recently, another nutritionally regulated hormone, FGF21, has
been proposed as a regulator of fertility in rodents based on the finding that
female mice overexpressing FGF21 to supraphysiologic levels (FGF21-Tg) have
delayed onset of puberty and remain infertile through adulthood [13]. In
this proposed model, FGF21 synthesized and secreted into the circulation by the
liver acts on the SCN to suppress the production of vasopressin (AVP) which further suppresses kisspeptin-1 (Kiss-1), an important regulator of fertility.” Read More
Source:(https://www.sciencedirect.com/science/article/pii/S221287781630045X)
Image Credit: Stacy Smith
“The majority of systemic bacterial infections are caused by endogenous pathogens from human microbiota, and the opportunistic pathogen Staphylococcus aureus, commonly found in the external opening of the nostrils, is one of the most clinically important because of the prevalence of multi-drug resistant strains”.. Read More
Source: (https://www.nature.com/nature/journal/v535/n7613/full/nature18634.html)
Take Advantage of Our Limited Time Special Offer
on Anti-GAD (Glutamic Acid Decarboxylase) ELISA Assay Kit
Kits are 1/2 price!
Cortisol Saliva ELISA is for Research Use Only. Not for diagnostic procedures.
Salivary cortisol has been found to be a good index of stress with increased levels of cortisol correlating positively with increased levels of
stress. Cortisol levels rise slowly over time and take a while to return to base level, indicating that cortisol is more
associated with chronic stress levels.
Diurnal variation is a major factor for within-person variance because baseline cortisol levels have been known to
differ based on the time of day. For normally developing individuals who follow a typical day–night schedule,cortisol
production peaks during the last few hours of sleep. This peak is thought to aid in preparing the body for action and
stimulate the appetite upon waking.Diurnal variation is also affected by psychological conditions.
For several years the gold reference standard for ELISA has been the RIA method.
Now Eagle Biosciences performed a new study with the support of Università Cattolica of Rome, comparing the ELISA
results with the LC-MS/MS technique (mass spectrometry), obtaining a very good correlation between the two
methods: R= 0.94.
This study has been performed on 63 samples from healthy subjects, collected in different time.
The Cortisol Saliva assay is now considered by scientific community a reliable alternative to Urinary Cortisol assay.
Why Use EagleBio’s Cortisol Saliva ELISA?
Making saliva one of the most accessible body fluids and potentially one of the most valuable in studying normal human physiology as well as pathology.
The majority of cortisol in saliva is not-bound and enters the saliva via intracellular mechanisms. Salivary cortisol levels are unaffected by salivary flow rate or salivary enzymes.
R= 0.94
Related Kits:
Steroid Assay Kits
Cortisol ELISA Assay Kit
Cortisol Saliva ELISA Assay Kit
Testosterone ELISA Assay Kit
Testosterone Saliva ELISA Assay Kit
Related News:
EagleBio’s Ultrasensitive Cortisol Saliva ELISA is a Valuable Tool in a Circadian Rhythmicity Study
Brain inflammation is also commonplace with Alzheimer’s disease. In June 2016’s Aging and Mechanisms of Disease, members of the Salk Institute team studied nerve cells altered to produce higher levels of the amyloid beta protein in order to mimic the conditions found in Alzheimer’s. High levels of the protein are associated with cellular inflammation and higher rates of neuronal death. Previously, it was thought that the inflammation occurred from immune cells, but an uncanny discovery proved otherwise—the amyloid beta proteins instead are the cause of inflammatory effects within the brain. Read More
Source:(https://agscientific.com)
EagleBio’s Intact FGF-21 was recently utilized in this Boston Study at Tufts University:
Human FGF-21 Is a Substrate of Fibroblast Activation Protein
FGF-21 is a key regulator of metabolism and potential
drug candidate for the treatment of type II diabetes and other metabolic
disorders. However, the half-life of active, circulating, human FGF-21 has
recently been shown to be limited in mice and monkeys by a proteolytic cleavage
between P171 and S172. Read More
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151269
Infection during pregnancy blunts development of the fetal brain by boosting levels of the chemical messenger serotonin, a new study suggests(1).
A wealth of data tie infection in a pregnant woman to a slightly increased risk of autism in her child. Prenatal exposure to inflammation is known to disrupt brain development and produce autism-like behaviors in mice. Read More
Source: (https://spectrumnews.org/news/serotonin)
Related Assays:
SEROTONIN ULTRASENSITIVE ELISA ASSAY KIT
