Tag: Eagle Biosciences

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Interesting New Research: Team develops promising Zika vaccine candidates

by Eagle Biosciences


Researchers around the world have been racing to develop a vaccine for the Zika virus, and it appears that a large team of US researchers have developed two very promising candidates.

According to a report published in the journal Nature, researchers developed one potential vaccine using a Zika virus isolated in Brazil, and another candidate using a Zika virus isolated in Puerto Rico. Preclinical results showed both candidates were able to protect mice against an infection with the Zika virus by stimulating the rodents’ immune system. Furthermore, neither candidate was found to have significant side effects. Read More


Source: (https://www.redorbit.com/news/health/1113414773/promising-zika-vaccine-candidates-062816)

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Herpes and Constipation: Firming Up a Loose Connection

by Eagle Biosciences

shutterstock_235683694

(Credit: Piotr Marcinski/Shutterstock) 


Constipation and an inability to empty the bladder are rare, but not unheard of, complaints from patients who acquire a genital herpes infection.

The thing is, doctors couldn’t say how these seemingly unrelated symptoms were linked to the infection. Now, a team led by Akiko Iwasaki, a professor of immunobiology at Yale University and a Howard Hughes Medical Institute investigator, has discovered a mechanism that directly ties the viral infection with gastrointestinal complications. Read More

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Recent UK Study Utilizes EagleBio’s Adrenaline and Noradrenaline ELISA

by Eagle Biosciences

A recent study by the University of Manchester in the UK used Eagle Biosciences’ Adrenaline (Epinephrine) ELISA Assay Kit and Noradrenaline (Norepinephrine) ELISA Assay Kit to measure adrenaline and noradrenaline respectively in mice.

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

It is becoming clear that intestinal microbiota play key roles in both host development and in maintaining homeostasis. Intestinal microbiota change with age and are also influenced by environmental factors such as diet, and disease (Flint et al., 2012, Wu, 2011 and Spor et al., 2011). Recent research highlights the key role of microbial communities in the large intestine in essential immune defence mechanisms and control of inflammatory responses (Abt et al., 2012 and Ganal et al., 2012). Impaired regulation of the intestinal microbiota is also known to contribute to diseases of the intestinal tract, and is linked with the development of diverse inflammatory conditions such as sepsis, metabolic disease or cancer (Ayres et al., 2012, Dupont and Dupont, 2011, Le Chatelier et al., 2013 and Yoshimoto et al., 2013). Read more

Related Kits:

Adrenaline (Epinephrine) ELISA Assay Kit

Noradrenaline (Norepinephrine) ELISA Assay Kit

BiCAT Adrenaline and Noradrenaline ELISA Assay Kit

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EagleBio’s New Addition to the Gate City Marathon and Relay: EagleBio Junior Team

by Eagle Biosciences

EagleBio had not one but TWO teams enter the Gate City Marathon and Relay this year, our original EagleBio Team from last year (a.k.a. Nerd Herd) and a new addition, the EagleBio Junior Team (a.k.a. Nyoko)

EagleBio Junior Team

Left to right: Steven, Matt, Will, Chris, and Ryan

EagleBio Junior Team

EagleBio Junior Team Crossing the finish line as a team.

EagleBio Junior Team proud of their medals and it is a true reflection of their hard work!


These boys run for two different middle schools and have been racing against each other at the local, state, regional, and even national level for years and finally got a chance to join forces running as EagleBio Junior Team.

Even when they are not running on the same team they motivate each other on the course and help each other to reach their goals. This is a group of talented young runners who truly enjoy the sport and they are an inspiration to other runners young and old!

They ran hard during the Gate City Marathon and Relay and had a ball in a true spirit of competition and friendship. They placed second with a time of 2:46:19!

Outstanding job to both our teams, we are so very proud of you!

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A Father’s Diet Affects the RNA of his Sperm

by Eagle Biosciences

A father's diet affects his offspring's genetic code

Image Credit: pixabay.com

Our genes make us. They decide our height, the sound of our voice, and even how athletic we are. We’ll always have the same set of genes throughout our lives. However, specific ones will activate or deactivate depending on what we do, consume, and experience on a daily basis.

(Source: https://www.labroots.com/trending/health-and-medicine/2168/a-father-s-diet-affects-the-rna-of-his-sperm )

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Fighting hospital germs with sugar

by Eagle Biosciences

Fighting hospital germs with sugar

Sweet spot for therapeutic antibodies: the illustration above shows the three-dimensional structure of the sugar molecule PS-I of C. difficile (orange: carbon; red: oxygen; white: hydrogen).Credit: MPI of Colloids and Interfaces


A vaccine against one of the most dangerous hospital germs may soon be available. Scientists from the Max Planck Institute of Colloids and Interfaces in Potsdam and the Freie Universität Berlin have developed a substance that elicits an immune response against the gut bacterium Clostridium difficile. The potential vaccine resembles the sugar structures presented on the surface of the bacterium and therefore primes the immune system to recognize the pathogen itself.C. difficile infects a large proportion of patients in hospitals and kills around 15,000 people a year in the USA alone. Doctors could treat the infection with antibiotics, but the bacterium mutates constantly, allowing it to escape the effects of the drugs. The discovery by the Max Planck researchers may pave the way for developing inexpensive and effective vaccines and drugs against C. difficile.


(Source: https://sciencebulletin.org/archives/1013.html)

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Product Higlights: Urocortin Assays

by Eagle Biosciences

EagleBio is happy to announce some new assays to our Endocrinology product line. We are now offering urocortin assays for testing mouse and rat serum or plasma.

Urocortin 2 (Ucn 2), also known as stresscopin-related peptide, is a novel predicted neuropeptide related to corticotropin-releasing factor (CRF).(3)

 

Why Measure Urocortin (Ucn2)?

  • Ucn 2 had been used in cardiovascular reseach related to treat ischemic heart disease because of because of its potent cardioprotective effect in the mouse heart (1).
  • Ucn 2 has also been used in bone metabolism and muscled wasting disease research related to loss of skeletal muscle mass resulting from disuse due to casting, corticosteroid treatment, and nerve damage. It has been discovered that Ucn 2 can increase skeletal muscle mass and force (2).
  • Mouse urocortin 2 (Ucn 2) is a new peptide and its physiological significance has not yet been fully elucidated. Experimental data presented to date provided evidence that there are important physiologic roles of Ucn 2 thus there is a great need for further investigation for various areas of research and points of view.

 

Eagle Biosciences Urocortin Assays:

RAT UROCORTIN 2 ELISA ASSAY KIT

MOUSE UROCORTIN 2 ELISA ASSAY KIT

MOUSE/RAT UROCORTIN 1 ELISA ASSAY KIT

MOUSE/RAT UROCORTIN 3 ELISA ASSAY KIT

 

 

References:

 

1. Brar BK. (2004) Urocortin II and urocortin III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart. Endocrinology., 145, 24-35

2. Hinkle RT. (2003) Urocortin II treatment reduces skeletal muscle mass and function loss during atrophy and increases nonatrophying skeletal muscle mass and function. Endocrinology., 144, 4939-4946

3. Reyes TM. (2001) Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci USA. 98, 2843-2848

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Eating chocolate each day could reduce heart disease, diabetes risk

by Eagle Biosciences




A new study published in the British Journal of Nutrition appears to back up the adage that a little of what you fancy does you good.

Including a small amount of chocolate each day could help prevent diabetes and insulin resistance. That’s one of the research findings from the Luxembourg Institute of Health (LIH), the University of Warwick Medical School, the University of South Australia and the University of Maine. Read More

(Source: https://www.sciencedaily.com/releases/2016/04/160428124108.htm )

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Boston Study: EagleBio’s Histamine ELISA

by Eagle Biosciences

 

EagleBio's Histamine ELISA

Histamine ELISA is for Research Use Only.

EagleBio’s Histamine ELISA was recently utilized in a study byBrigham and Women’s Hospital and Harvard Medical School. Histamine ELISA  a kit designed for the quantitative determination of histamine in plasma, urine, and cell culture. This assay is part of our Immunology Assay Kit line which is comprised of a unique,versatile set of products for a variety of applications, research, and fields of study.

New Publication:

Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages 

Mast cells (MCs) contribute to the pathogenesis of obesity and diabetes. This study demonstrates that leptin deficiency slants MCs toward anti-inflammatory functions. MCs in the white adipose tissue (WAT) of lean humans and mice express negligible leptin. 

(Source: www.researchgate.net/publication/283050874)