EagleBio is happy to announce some new assays to our Endocrinology product line. We are now offering urocortin assays for testing mouse and rat serum or plasma.
Urocortin 2 (Ucn 2), also known as stresscopin-related peptide, is a novel predicted neuropeptide related to corticotropin-releasing factor (CRF).(3)
Why Measure Urocortin (Ucn2)?
- Ucn 2 had been used in cardiovascular reseach related to treat ischemic heart disease because of because of its potent cardioprotective effect in the mouse heart (1).
- Ucn 2 has also been used in bone metabolism and muscled wasting disease research related to loss of skeletal muscle mass resulting from disuse due to casting, corticosteroid treatment, and nerve damage. It has been discovered that Ucn 2 can increase skeletal muscle mass and force (2).
- Mouse urocortin 2 (Ucn 2) is a new peptide and its physiological significance has not yet been fully elucidated. Experimental data presented to date provided evidence that there are important physiologic roles of Ucn 2 thus there is a great need for further investigation for various areas of research and points of view.
Eagle Biosciences Urocortin Assays:
1. Brar BK. (2004) Urocortin II and urocortin III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart. Endocrinology., 145, 24-35