The Eagle Biosciences NT-proCNP ELISA Assay Kit (manufactured by Biomedica) was used in a recent study published out of the University of Otago in Christchurch, New Zealand. This kit is used for the quantitative determination of NT-proCNP in human serum and plasma (EDTA, citrate, heparin). CNP, C-type natriuretic peptide, along with other natriuretic peptides, plays a role in regulatory mechanisms including blood pressure and body fluid homeostasis. It also serves as a biomarker.

Plasma C-Type Natriuretic Peptide: Emerging Applications in Disorders of Skeletal Growth

Abstract


Although studies in experimental animals show that blood levels of C-type natriuretic peptide (CNP) and its bioinactive aminoterminal propeptide (NTproCNP) are potential biomarkers of long bone growth, a lack of suitable assays and appropriate reference ranges has limited the application of CNP measurements in clinical practice. Plasma concentrations of the processed product of proCNP, NTproCNP – and to a lesser extent CNP itself – correlate with concurrent height velocity throughout all phases of normal skeletal growth, as well as during interventions known to affect skeletal growth in children. Since a change in levels precedes a measurable change in height velocity during interventions, measuring NTproCNP may have predictive value in clinical practice. Findings from a variety of genetic disorders affecting CNP signaling suggest that plasma concentrations of both peptides may be helpful in diagnosis, provided factors such as concurrent height velocity, feedback regulation of CNP, and differential changes in peptide clearance are considered when interpreting values. An improved understanding of factors affecting plasma levels, and the availability of commercial kits enabling accurate measurement using small volumes of plasma, can be expected to facilitate potential applications in growth disorders including genetic causes affecting the CNP signaling pathway.

Espiner, E.; Prickett, T.; Olney, Robert; (2019). Plasma C-Type Natriuretic Peptide: Emerging Applications in Disorders of Skeletal Growth. Horm. Res. Paediatr., 90:345–357. DOI: 10.1159/000496544

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Interesting Study Highlighting Eagle Biosciences’ BNP Fragment ELISA Assay Kit



A recent study was published in Stroke has sited using our BNP Fragment (Nt-proBNP 8-29) ELISA Assay Kit from Biomedica to determine if BNP(Brain natriuretic peptide) levels were associated with functional outcome after ischemic stroke. Researchers concluded that there was in fact a strong, reliable association with cardioembolic stroke as well as a prediction of functional outcome and mortality.


Check out the links below, visit the Eagle website, www.EagleBio.com, or call 866-411-8023 for full details.


Brain Natriuretic Peptide Predicts Functional Outcome in Ischemic Stroke

Rost NS et al., Stroke, Feb 2012; 43:441-445


Related Kits:

BNP Fragment (Nt-proBNP 8-29) ELISA Assay Kit