Vitamin B1 Microtiter Plate Assay Kit
Vitamin B1 Microtiter Plate Assay Kit manufactured in Germany by Immundiagnostik
Size: 1×96 wells
Sensitivity: 3 µg/L
Dynamic Range: 3 – 15 µg/L
Incubation Time: 24 hours
Sample Type: Whole Blood
Sample Size: 100 µL
Alternative Names: Thiamin, thiamine pyrophosphate, thiamine
For Research Use Only
Vitamin B1 concentration was determined in 42 samples of blood donors. The median value of this set of numbers was 48.1 (44.3) µg/ L. The array of 2-SD was 30- 66 µg/L.
Please note: A concentration range of 30-150 µg/l Vitamin B1 is covered at a sample dilution 1 :10. We recommend each laboratory to develop its own normal range as normal ranges depend on the choice of patient collective. The values mentioned above are only for orientation and can deviate from other published data.
The bioactive form of vitamin B1 is thiamine pyrophosphate. It plays an important role as a coenzyme in carbohydrate and amino acid metabolism. Thiamine pyrophosphate is a vital co-factor for enzymes involved in several key metabolic processes in the nervous system, the heart, the blood cells, and the muscle. Vitamin B1 assists in the conversion of carbohydrates into energy, necessary for healthy brain and nerve cells and heart function.
Vitamin B1 deficiency may result from a deficiency in the diet. Eventually, a severe vitamin B1 deficiency may lead to BERI-BERI, characterized by nerve, heart, and brain abnormalities. Deficiency may occur in alcoholics or in special clinical situations such as hemodialysis, chronic peritoneal dialysis, or after administration of glucose to a vitamin B1-depleted patient. Further vitamin B1 deficiency diseases are Wernicke’s encephalopathy, Korsakow-syndrome, and some forms of Landry’s paralysis. Also, myopathy was found in relation to thiamine deficiency.