The Eagle Bioscience’s Rat IGFBP-5 is for research use only and not to be used for diagnostic procedures.
Expressed in an Origami B cell expression system and purified by affinity chromatography.
Rat insulin-like growth factor binding protein-5 (IGFBP-5) is a 252 amino acid protein which preferentially binds IGF-II compared to IGF-I. It is highly conserved with a single amino acid difference [Asp187] compared to mouse IGFBP-5 [Glu187] and approximately 97% sequence homology to human IGFBP-5. It is functionally similar to human IGFBP-5 and inhibits the effects of IGF peptides. It binds to extra-cellular matrix proteins which protect it from proteolysis and modify its biological functions.
- Purity: >90 % (by SDS PAGE)
- Quantity: 10 µg
- Molecular Weight: Non-glycosylated mouse IGFBP-5 is 28.5 kDa
- Biological Activity: Binds IGF-I in Western ligand blot. Binding affinity for IGF-I – 0.2nM (Biosensor)
- Endotoxin (LAL): <0.1 EU/ug
- Storage/Stability: At least 2 years at 2-4°C (lyophilized)
- Appearance: White powder
- State: Freeze-dried from 0.1M acetic acid and stored under nitrogen at a slight vacuum.
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