Lipoxin A4 ELISA Assay
The Lipoxin A4 ELISA Assay is For Research Use Only
Size: 1×96 wells
Sensitivity: 0.02 ng/ml
Dynamic Range: 0.02 – 20 ng/ml
Incubation Time: 2 hour
Sample Type: Biological Fluids
Sample Size: 100 µl
Product manufactured in the USA
Assay Background
Lipoxin A4 (LXA4) is a biologically active lipoxygenase interaction product derived from arachidonic acid. Arachidonic acid is first oxygenated by 15-lipoxygenase to form 15-HETE which is converted by 5-lipoxygenase and epoxide hydrase to generate LXA4. LXA4 stimulates leukocyte chemotaxis without aggregation and inhibits natural killer cell cytotoxicity. It also provokes contraction of parenchymal strips and stimulates microvascular changes. Recent findings indicate that LXA4 inhibits leukocyte-dependent inflammation. Determination of LXA4 level may provide new understanding of the role of LXA4 in basic cellular reactions and in pathophysiology of inflammation and other disease processes.
CROSS-REACTIVITY
Lipoxin A4 100.0%
15-epi- Lipoxin A4 24%
5(S)6(R)-Di-HETE 5.00%
Lipoxin B4 1.00%
15-HETE 0.10%
5-HETE <0.10%
12-HETE <0.10%
Leukotriene B4 <0.01%
Leukotriene C4 <0.01%
Leukotriene D4 <0.01%
Leukotriene E4 <0.01%
STORAGE
1. Store the components of this kit at the temperatures specified on the labels.
2. Unopened reagents are stable until the indicated kit expiration date.
3. Concentrated, reconstituted conjugate has a shelf life of at least two weeks when stored properly.
4. Desiccant bag must remain in foil pouch with unused strips. Keep pouch sealed when not in use to maintain a dry environment. Remove excess air before sealing.
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