Human Pro-IGF-II (1 - 156)

Human Pro-IGF-II (1 – 156)

$190.00

Pro-Insulin-like Growth Factor II (Pro-IGF-II) is a 156-amino acid precursor protein derived from a single IGF-II transcript, which includes an 89-amino acid E-domain. It undergoes glycosylation and sequential proteolytic cleavage to generate various isoforms, some of which remain partially processed and contribute to 10–20% of circulating IGF-II. This reagent is intended for research use only and is not for diagnostic or therapeutic applications.

SKU: AHU020 Category: Tags: , ,

The IGF-II gene encodes a single transcript which results in a 156 amino acid protein, including an 89 amino acid E-domain. Pro-IGF-II is converted to mature IGF-II by sequential cleavage at amino acids 104, 87 and 67. Pro-IGF-II contains sites of O-linked glycosylation. Differential glycosylation and cleavage within the E-domain can therefore result in multiple pro-IGF-II isoforms. The pro-IGF-II proteins make up 10-20% of circulating IGF-II. Pro-IGF-II proteins are secreted by some tumour cell lines and levels are elevated in non-islet cell tumour hypoglycaemia.

This product is manufactured in Australia by GroPep Bioreagents.

Size 20 µg
Source Species Recombinant
Expression System Ecoli
Storage 2-8°C
Alternative Names Pro-Insulin-like Growth Factor II (Pro-IGF-II)

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