Human MANF Mouse Monoclonal Antibody
The Human MANF Mouse Monoclonal Antibody is For Research Use Only
Immunogen: Human MANF
Uniprot ID: P55145
Alternative Names: ARMET, ARP
Clonality: Mouse monoclonal
Reactivity: Human MANF
Application: ELISA, WB
Purification: IgG fraction purified with Protein G affinity chromatorgaphy
Buffer: PBS pH 7.4, with 0.1% sodium azide
Concentration: 1 mg/ml
Unit Size: 100 µg
Related Products: Monoclonal and polyclonal antibodies to human MANF.
Shipping: This product is shipped in non-frozen liquid form in ambient conditions.
Storage: Store at –20 to -70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles.
Alternative Names: Mesencephalic astrocyte-derived neurotrophic factor
Protocol: ELISA 1:32 000; Western immunoblotting 1:2000 – 1:4000
Monoclonal antibody working titer has to be established practically for each particular antigen and assay format.
Background: MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson’s disease (Lindholm et al., 2008, Voutilainen et al., 2009). When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta