Human IGFBP-3

$420.00

The Eagle Bioscience’s Human IGFBP-3 is for research use only and not to be used for diagnostic procedures.

SKU: BP3BU100 Categories: ,

Human IGFBP-3

The Eagle Bioscience’s Human IGFBP-3 is for research use only and not to be used for diagnostic procedures.


Product Specifications

Source:

Expressed in a mammalian cell expression system and purified by a series of chromatography steps. 

Description:

Human Insulin-like growth factor binding protein-3 (IGFBP-3) is a 264 amino acid protein which is a member of a family of six circulating proteins that bind IGF-I and IGF-II with high affinity and modulate their metabolic and mitogenic effects. Human IGFBP-3 is a 40-44 kDa glycoprotein that is the most abundant IGFBP in serum and milk. It is produced by non-parenchymal hepatic cells and circulates in serum, binding IGF-I or IGF-II in conjunction with an acid labile subunit (ALS) to form a (1:1:1) 150 kDa circulating complex at a serum concentration of about 100 nM. Phosphorylation of IGFBP-3 also affects its biological activity. 

  • Purity: ≥ 90 % (by HPLC anaylsis)
  • Quantity: 100 µg
  • Molecular Weight: Glycosylated IGFBP-3 is 43-45 kDa. Non-glycosylated IGFBP-3 is 28.76 kDa. 40-45 kDa characteristic doublet of glycosylated IGFBP-3 detected by Western ligand blotting using biotinylated IGF-II
  •  N-terminal sequence: Analysis of 5 residues
  • Endotoxin (LAL): <0.1 EU/ug
  • Storage/Stability: At least 2 years at 2-8°C (lyophilized)
  • Appearance: White Powder
  • State: Dried from 0.1M acetic acid and stored under nitrogen at a slight vacuum.

Related Products

Functional IGFBP-3 LIA Assay
Rodent IGFBP-3 ELISA Assay
IGFBP-3 ELISA Assay Kit

Documents

Product Manual


Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations