Anti-CaSR IgG ELISA Kit
Anti-CaSR IgG ELISA Kit Developed and Manufactured in the USA
Size: 1×96 wells
Sensitivity: 2.5 U/mL
Dynamic Range: 10 – 270 U/mL
Incubation Time: 2.0 hours
Sample Type: Serum, Plasma, Tissue extract
Sample Size: 100 µL
Alternative Names: Calcium-Sensing Receptor IgG
For Research Use Only
The human calcium-sensing receptor (CaSR) is a 1078 amino acid cell surface protein, which is predominantly expressed in the parathyroid glands and kidney. It is a member of the family of G protein-coupled receptors. The CaSR allows regulation of parathyroid hormone (PTH) secretion and renal tubular calcium reabsorption in response to alterations in extracellular calcium concentrations. Abnormalities of the CaSR are associated with both hypercalcaemic and hypocalcaemic disorders.
The human CaSR gene is located on chromosome 3q21.1 and loss-of-function CaSR mutations have been reported in the hypercalcaemic disorders of familial benign hypocalciuric-hypercalcaemia (FHH, FBH or FBHH) and neonatal severe primary hyperparathyroidism (NSHPT).
CaSR auto-antibodies have been found in FHH patients who did not have loss-of-function CaSR mutations, and in patients with an acquired form (i.e. autoimmune) of hypoparathyroidism. Autoimmune hypoparathyroidism can occur as an isolated clinical abnormality, as part of autoimmune polyendocrinopathy syndrome (APS)-1 or as part of APS-2. APS-1 most commonly comprises mucocutaneous candidiasis, hypoparathyroidism, and Addison’s disease. APS-2 includes two or more of the following: Addison’s disease, Graves’ disease, autoimmune thyroiditis, type 1 diabetes mellitus, primary hypogonadism, myasthenia gravis, or celiac sprue. Studies have demonstrated that CaSR autoantibody is present in about one third of the patients with isolated acquired hypoparathyroidism. On the other hand, it is also reported that some clinical primary hypoparathyroidism can harbor autoantibodies to human CaSR. Therefore, there is a great clinical value of detecting this autoantibdy to assess the autoimmune origin of the disease.