ADMA Arginine ELISA Assay Kit
ADMA Arginine ELISA Assay Kit manufactured in Germany as SKU EA207/96 by DLD Diagnostika
Size: 1×96 wells
Sensitivity: ADMA: 0.01 µmol/L, Arginine: 3.0 µmol/L
Dynamic Range: ADMA: 0.1 – 5.0 µmol/L, Arginine: 6-600 µmol/L,
Incubation Time: Overnight
Sample Type: EDTA Plasma
Sample Size: 20 µL
For Research Use Only
Reference Values for the ADMA Arginine ELISA Assay Kit (Normal)
ADMA 0.4 – 0.75 µmol/l
Arginine 20 – 80 µmol/l
It is suggested that each laboratory establish its own normal ranges.
Nitric oxide (NO which is formed in the vascular endothelium plays a crucial role in the regulation of vascular structure and function. NO has been named an “endogenous anti-atherogenic molecule” due to its diverse regulatory functions in vascular homeostasis. NO is formed by the enzyme NO synthase (NOS) from the amino acid precursor L-arginine. NOS activity is inhibited by asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NOS.
The effects of ADMA on NO synthesis and NO-mediated pathophysiological processes have been described in numerous experimental and clinical studies, including samples with hypercholesterolemia, hypertension, chronic heart failure, chronic renal failure and other internal disorders. Elevated ADMA levels are a risk factor for future cardiovascular events and total mortality, as evidenced by prospective clinical studies comprising more than 10,000 participants. Thus, studies have shown that ADMA has diagnostic relevance as a novel cardiovascular risk marker.
Importantly, high ADMA levels and low L-arginine/ADMA ratio were both independent predictors of death in the community-based Framingham Offspring Study. As ADMA competes with L-arginine for binding to NO synthase, many scientists suggest that the L-arginine/ADMA ratio is a better index of NOS substrate availability and, thus, functional integrity of the NOS pathway, than L-arginine levels alone.
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For a Full Listing of Publications utilizing these ADMA ELISA Assay kits, click on the link below:
ADMA ELISA Assay Kit Publications
Learn more about ADMA at Eagle Biosciences Biomarker Spotlight page dedicated to ADMA here:
ADMA Biomarker Spotlight