Sclerostin expression in trabecular bone is down-regulated by osteoclasts

Scientific Reports

Bone tissues have trabecular bone with a high bone turnover rate and cortical bone with a low turnover. Expression of sclerostin by osteocytes works to inhibit bone formation. A study performed recently aimed to evaluate the relationship between the secretion of sclerostin by osteocytes and the secretion of leukemia inhibitory factor (LIF) by osteoclasts. It was found that LIF secretion effectively suppresses sclerostin expression and promotes bone formation.

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