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Cancer treatment on a cellular level

by Eagle Biosciences

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CREDIT: (CREDIT: BORDALLO AND MARTINS, NIELS BOHR INSTITUTE)

The most common treatments for cancer are radiation and chemotherapy. However they have side effects and also damage healthy tissues. Moreover, their effectiveness is limited when the cancer has spread through out the body. Researchers at the Niels Bohr Institute are therefore working to develop a gentler treatment that ‘tricks’ the cancer cells, which would absorb a cytotoxin and therefore be destroyed, while healthy cells would remain unaffected. The results are published in the scientific journal, Scientific Reports. Read More


(Source: https://www.eurekalert.org/pub_releases/2016-03/uoc–cto022916.php)

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New study indicates why children are likelier to develop food allergies

by Eagle Biosciences


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IMAGE: A STUDY BY LJI RESEARCHERS IDENTIFIED A T CELL POPULATION THAT RENDERS NORMAL FOOD NON-ALLERGENIC. PHOTO CREDIT: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY


LA JOLLA, CA–An estimated 15 million Americans suffer from food allergies, many of them children. These are non-trivial concerns, as food allergy or intolerance can cause symptoms ranging from a harmless skin rash to a potentially lethal anaphylactic shock. The good news is that many affected children outgrow their allergy, presumably as the immune system learns to tolerate food initially mistaken as “foreign”. Read more


(Source: https://www.eurekalert.org/pub_releases/2016-01/ljif-nsi012516.php)

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Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation

by Eagle Biosciences



Major progress has been made in recent years to produce functional insulin+ cells for cell replacement therapies to treat diabetes. These regenerative technologies include directed differentiation of embryonic stem cells and direct conversion from non-β cells such as liver cells, acinar cells, and others (Hebrok, 2012,Johannesson et al., 2015, Nostro and Keller, 2012, Schiesser and Wells, 2014,Zhou and Melton, 2008). Read more 

(Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)00004-7)

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Cancer-causing gene found in plasma may help predict outcomes for head and neck patients

by Eagle Biosciences


Trisha Wise-Draper, MD, PhD. (credit: Joe Fuqua, University of Cincinnati)


Researchers at the University of Cincinnati (UC) have discovered that a human cancer-causing gene, called DEK, can be detected in the plasma of head and neck cancer patients. DEK may help doctors understand how a person’s immune system could be used to treat cancer or predict outcomes for patients.


(Source:  https://www.eurekalert.org/pub_releases/2016-02/uoca-cgf021516.php)

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Complement Assays by EagleBio

by Eagle Biosciences

 

Product Highlights

EagleBio’s Complement Assays are for Research Use only in the US. Not to be used for diagnostic procedures.

 

Eagle Biosciences’ Oxidative Stress Assay Kit line offers a complete group consisting of numerous valuable products for assisting scientists in fields of research such as diabetes, cancer, aging, and other similar areas of study.

Some of the most valuable kits in our Oxidative Stress Kit line are the Complement ELISA Assays which are unique, simple, objective, and effective methods for assessing the function of complement activity. Individually, each of these assays: Complement System Screen ELISA, Classical Pathway ELISA, MBL Pathway ELISA, and Alternative Pathway ELISA offer a variety of advantages over other competing kits such as ease of use and maximum accuracy. Collectively, this comprehensive line provides researchers with a kit for every complement research need by the ability to measure the three pathways separately or all three pathways together in one kit.

Why Measure Complement Activity with EagleBio’s Kits?

Evaluation of total complement function is essential in laboratory testing of the human complement system. Measuring all three pathways is the sure way to provide and accurate assessment of:

      • Complement activity of each individual pathway (Classical, MBL, Alternative)
      • Complement activity of the system as a whole
      • Individual and collective ability of pathways to perform various biological activities within the functional innate immune system.

EagleBio’s Complement Assays Kits are the only kits in the market to provide a complete picture of complement function.

 

 

Key Advantages of EagleBio’s Complement Assay Kit Line:

      • Simple ELISA methods vs cumbersome hemolytic assay methods of other competing assay lines. Our ELISAs provide amazing simplicity for several aspects:

        • Test Procedure
        • Result Interpretation
        • Automation
        • Standardization
      • Innovative and uniformly designed Complement Screen ELISA Kit to assess the whole complement system (all three pathways: Classical, MBL, Alternative) in one simple ELISA.
      • 3 Uniquely designed kits for measuring each individual pathway (Classical, MBL, Alternative) vs most competing kits that measure the Terminal Complement Complexes (TCC) as a measure of activity.

 

Related Kits:

Total Complement Functional Screen ELISA

Complement Classical Pathway ELISA Assay Kit

Complement Alternative Pathway ELISA Assay Kit

Complement MBL Pathway ELISA Assay Kit

 

Immunology Assay Kits

Related News:

EagleBio Spotlight: Complement System

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IGFBP-6 ELISA by EagleBio

by Eagle Biosciences

Product Highlights: IGFBP-6 ELISA


 

IGFBP-6 ELISA is for Research Use Only

 

Eagle
Biosciences’ Endocrine Assay Kit Line that consists of a comprehensive
product grouping of unique and sensitive assays for measuring a variety of
analytes for diabetes and obesity research. Our IGFBP-6 ELISA is one of the exceptional assays in this Endocrine Assay Kit Line that offers a reliable method for
measuring IGFBP-6 concentrations in serum, plasma and cell culture
supernatants.

Why Measure IGFBP-6?

Insulin-like
Growth Factor Binding protein 6 (IGFBP-6) has been identified to be a selective
inhibitor of IGF-II activities such as proliferation, survival and
differentiation of cells. According to a recent publication, Bach, L. this marker
has been shown to have a number of IGF-independent actions, involving promotion
of apoptosis in some cells and inhibition of angiogenesis. It is because of these roles that IGFBP-6
should be studied further in various fields of research[1].

EagleBio’s IGFBP-6 ELISA allows secure and reproducible measurement of IGFBP-6 in
human body fluids and is a suitable tool for the study of IGFBP-6 in growth,
cancer and bone metabolism.

Key Advantages of EagleBio’s IGFBP-6
ELISA:

  • Excellent specificity
  • High sensitivity
  • Wide dynamic Range
  • Small sample size

References:

1.Bach, L. Recent insights into the actions of IGFBP-6 J Cell Commun Signal 2015: 9(2): 189–200.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458248/

Related Products:

Multispecies
IGF-1 ELISA

IGFBP-4
ELISA ASSAY KIT

FUNCTIONAL
IGFBP-3 ELISA

IGFBP-3
ELISA ASSAY KIT

MOUSE/RAT
IGFBP-2 ELISA ASSAY KIT

Endocrine
Assay Kits

 

Categories

Study: Obesity Surgery May Cure Diabetes

by Eagle Biosciences



A new study gives the strongest evidence yet that obesity surgery can cure diabetes. Patients who had surgery to reduce the size of their stomachs were five times more likely to see their diabetes disappear over the next two years than were patients who had standard diabetes care, according to Australian researchers.

(source: https://www.foxnews.com/story/2008/01/23/study-obesity-surgery-may-cure-diabetes.html)

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Eagle Biosciences Announces the Launch of Functional Leptin ELISA

by Eagle Biosciences

An Esoteric Kit for Measurement of Functional, Receptor
Binding Leptin levels in Serum or Plasma

Nashua, NH January 25, 2016: Eagle Biosciences today announced the launch
of a new assay, Functional
Leptin ELISA. This assay was
developed and manufactured by Mediagnost
in Germany. Mediagnost offers a wide
range of top-notch biotechnology services and products which include test
systems for multiple applications with a strong focus in the fields of
infectious diseases, endocrinology, and neurology.

“We are certainly excited to have yet another great product from
Mediagnost to offer our customers to further support their endocrinology
research needs. Eagle Biosciences continues to improve and expand its assay
portfolio searching for esoteric assay kits like, Functional
Leptin ELISA,” said Dan Keefe, President of Eagle Biosciences.

“This assay is not only a sensitive and specific, but it
also provides results within 4 hours. Functional
Leptin ELISA is based on immobilized soluble leptin receptor and a highly specific
polyclonal antibody, allowing researchers to measure biologically active /
receptor binding leptin only.” Keefe continued, “These features certainly make
this kit a great addition to the Endocrine Assay Kit Line
at Eagle Biosciences.”

This product is currently for research use. Check out the links below, visit the Eagle
website, www.EagleBio.com, or call 866-411-8023
for full details.

Categories

EagleBio’s Vitamin D ELISA Utilized in University of Albany Study

by Eagle Biosciences


 

A recent study was conducted by the University of Albany Cancer Research Center using Eagle Bioscience’s 25-OH Vitamin D ELISA from our Vitamin Assay Kit Line. The Vitamin Assay Kit line offered Eagle Biosciences provides unique and sensitive assays for measuring a variety of vitamin analytes in numerous fields of research.  Check the product page for full details on our 25-OH Vitamin D ELISA or view the links below for information about the study referencing this kit.

 

Citation

Adipose-specific Vdr deletion alters body fat and enhances mammary epithelial density

 

Study Summary:

The objective of this study was to examine the role of Vitamin D Receptor (VDR) in adipose tissue with a strong focus on the mammary gland. Vitamin D status has been associated with obesity, metabolic syndrome and several cancers such as colon and breast. It is known that adipocytes express VDR and obesity is a known risk factor for cancer. Researchers performing this study sought to explore the intricacies of adipocytes,the actions of vitamin D in adipose tissue, and how they may contribute to its cancer protective effects. 

The results of this study revealed that Vdr in mature adipocytes alters the metabolic response to high fat diets and exerts anti-proliferative effects on the mammary epithelium.

Eagle Biosciences’ 25-OH Vitamin D ELISA was used to measure 25-hydroxyvitamin D in serum samples. Read More

 

Related Kits:

Vitamin Assay Kits

25-OH VITAMIN D HPLC ASSAY KIT

Vitamin B6 Whole Blood HPLC Assay Kit

Related News:

EagleBio Spotlight: Vitamin D

Interesting Study Reveals Possible Link Between Vitamin D and Autism

New Publications for Select Vitamin Assays Kits