Major progress has been made in recent years to produce functional insulin+ cells for cell replacement therapies to treat diabetes. These regenerative technologies include directed differentiation of embryonic stem cells and direct conversion from non-β cells such as liver cells, acinar cells, and others (Hebrok, 2012,Johannesson et al., 2015, Nostro and Keller, 2012, Schiesser and Wells, 2014,Zhou and Melton, 2008). Read more