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Product Hightlights: Periostin ELISA Assay Kit

Periostin ELISA is designed for the quantitative determination of human Periostin in serum and plasma and is for Research Use Only. This assay is part of Eagle Biosciences’ Bone Metabolism Line which is a comprehensive portfolio of assays for detecting and monitoring numerous biomarkers for the regulation of bone and mineral homeostasis, assisting researchers in various fields of study.

Highlights

• Extensively validated
• 7 human serum based standards and 2 controls
• CE registration in progress

Related Areas of Research:

Osteology, tissue repair, cardiovascular disease, oncology, respiratory disease

Learn More

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Metformin Plus Syrosingopine Effectively Combats Cancer Cells

by Eagle Biosciences

Bengtsson, M. Metformin Plus Syrosingopine Effectively Combats Cancer Cells. December 27, 2016 Retrieved from: www.reliawire.com.

“A combination of a diabetes medication and an antihypertensive drug effectively fights cancer cells, according to a team of researchers at the University of Basel. They also report that specific cancer cells respond to this combination of drugs.” Read More

Source: (https://reliawire.com/metformin-syrosingopine-cancer/)

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EagleBio’s New Drug Monitoring Assays

by Eagle Biosciences

Assays below are For Research Use Only.

EagleBio’s New Drug Monitoring Assays:

Eagle Biosciences is pleased to offer 3 new assays to the Drug Monitoring Assay Kit line which offers a unique grouping of products that provide incredible value to pre-clinical and clinical pharmacology studies, cancer research, and more specifically antitumor therapeutic investigation and more.

- - NF alpha Neutralization Rate/Adalimumab ELISA Assay Kit
    - Simultaneously determination:
      - Free TNFα target antigen
      - Available therapeutic antibody Adalimumab
      - Adalimumab’s ability to neutralize TNFα
- - TNF alpha Neutralization Rate/Infliximab ELISA Assay Kit:
    - Simultaneously determination:
      - Free TNFα target antigen
      - Available therapeutic antibody Infliximab
      - Infliximab’s ability to neutralise TNFα
  - Deoxynivalenol ELISA Assay Kit
    - Unique Assay for Determination:
      - Deoxynivalenol in food and feed crops

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Washington Study Uses Eagle Biosciences’ Biotinlylated Insulin

by Eagle Biosciences

EagleBio’s Human Insulin, Biotinylated (Biotin-Insulin) was recently utilized in a Washington State University Study. This recombinant human insulin is a part of our Endocrine product line that offers a comprehensive product grouping of unique for measuring a variety of analytes for diabetes and obesity research.

Citation:

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites

“Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice.”

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Anti-Inflammatory Drugs Might Someday Treat Depression

by Eagle Biosciences

Kappelmann, N. et al. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Molecular Psychiatry.2016 00, 1–9. https://dx.doi.org/10.1038/mp.2016.167

“In the future, a new class of anti-inflammatory drugs could be used to treat depression, say University of Cambridge researchers.

Drugs such as aspirin and ibuprofen treat inflammation, the body’s immune response to infections or pathogens. During an inflammatory response, immune cells flood the bloodstream with proteins known as cytokines.” Read More

Source: (https://edition.cnn.com/2016/10/18/health/anti-inflammatory-drugs-depression)

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EagleBio’s Norepinephrine ELISA Assay Kit in Nebraska Study

by Eagle Biosciences

Eagle Biosciences Norepinephrine ELISA Assay Kit was utilized in a recent Nebraska study (see below):

Shyra, Sundar Nandi et al. Lack of miR-133a Decreases Contractility of Diabetic Hearts: A Role for Novel Cross Talk Between Tyrosine Aminotransferase and Tyrosine Hydroxylase. Diabetes 2016 Oct; 65(10): 3075-3090. https://dx.doi.org/10.2337/db16-0023.

“MicroRNAs (miRNAs) have a fundamental role in diabetic heart failure. The cardioprotective miRNA-133a (miR-133a) is downregulated, and contractility is decreased in diabetic hearts. Norepinephrine (NE) is a key catecholamine that stimulates contractility by activating β-adrenergic receptors (β-AR). NE is synthesized from tyrosine by the rate-limiting enzyme, tyrosine hydroxylase (TH), and tyrosine is catabolized by tyrosine aminotransferase (TAT).” Read More

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Texas Study Utilizes EagleBio’s DM1 Antibody Drug Conjugate (ADC) ELISA

by Eagle Biosciences

EagleBio’s DM1 Antibody Drug Conjugate (ADC) ELISA ASSAY Kit was recently used in a Texas Tech University Health Sciences Center study. This assay is part of our Drug Monitoring Assay Kit line which offers a unique grouping of assays that provide incredible value to pre-clinical and clinical pharmacology studies, cancer research, and more specifically antitumor therapeutic investigation and more.

Yao H-P, Feng L, Zhou J-W, Zhang R-W, Wang M-H. Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment. American Journal of Cancer Research. 2016;6(5):937-956. PMID:27293990

“Blood samples were collected at different time intervals. DM1-coupled Zt/g4 was measured using a DM1 antibody ELISA kit (EagleBiosciences, Inc., Nashua, NH).”

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EagleBio’s Calprotectin ELISA Used in Recent NYU Study

by Eagle Biosciences

Eagle Biosciences’ Calprotectin ELISA was recently utilized in an NYU study. The researchers presented this abstract in a poster presentation at DDW 2016.

Citation:

The Use of Fecal Calprotectin to Understand the Expanded Utility of IBD Clinical Disease Activity and Quality of Life Assessments in Crohn’s Disease and Ulcerative Colitis

David Hudesman, Arun Swaminath, Dana J. Lukin, Mitchell Bernstein, Lisa Malter,
Melissa H. Rosen, Garrett Lawlor, Matthew Gross, Zoya Grigoryan, Arielle Radin, Michael
Tuen, Alexandra Feathers, Martin J. Wolff, Eve Frangopoulos, Martin J. Blaser, Huilin Li,
Lea Ann Chen

Fecal calprotectin levels were determined by EagleBio’s Calprotectin ELISA. The Eagle Biosciences Calprotectin ELISA Assay kit is intended for use in the quantitative determination of human calprotectin (neutrophil cytoplasmic protein S100A8/A9, MRP 8/14) levels in stool samples via Enzyme-linked immunosorbent assay. This assay kit is for research use only and should not be used in diagnostic procedures. Learn More

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Study Finds Potential New Biomarker for Cancer Patient Prognosis

by Eagle Biosciences

Image Credit:ZOSIA ROSTOMIAN/BERKELEY LAB

Study finds potential new biomarker for cancer patient prognosis

“To treat or not to treat? That is the question researchers at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) hope to answer with a new advance that could help doctors and their cancer patients decide if a particular therapy would be worth pursuing” Read More

Source:(https://www.eurekalert.org/pub_releases/2016-08/dbn. ).

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New Immunogenecity Symposium: October 5-7, 2016

by Eagle Biosciences

The 4th Coral Gables Symposium

Biltmore Hotel, Miami, FL

October 5-7, 2016

This years´ Coral Gables Symposia will provide a unique forum for thought leaders to address the principal concerns regarding immunogenicity and the patient. In particular, how an understanding of the immune response to biopharmaceuticals can benefit the patient both in terms of optimizing therapy, mitigating side effects, and improving outcome.