Active Human Recombinant Tau441 (2N4R), P301S mutant PPF


Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) when tau preformed fibrils (SPR-329) are combined with tau monomers (SPR-327).

SKU: SPR-329 Categories: ,

Active Human Recombinant Tau441 (2N4R), P301S mutant PPF

For Research Use Only

Specificity: ~45.8 kDa
Species: Human
Expression System: E. coli
Buffer: 10 mM HEPES, 100 mM NaCl pH 7.4
Storage Temperature: -80ºC

Product manufactured in Canada by StressMarq.

Additional Information

Assay Background

Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).

Comparative Protein Graph


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