Tau-352 (fetal 0N3R) Monomers

$510.00

The Tau-352 (fetal 0N3R) Monomers is intended for research use only and not for use in diagnostic or clinical procedures. Contact us for bulk pricing.

SKU: SPR-490B Categories: ,

Tau-352 (fetal 0N3R) Monomers

Tau-352 (fetal 0N3R) Monomers are For Research Use Only

Size: 100 ug
Species: Human
Expression System: E. coli
Buffer: 10 mM Hepes pH 7.4, 100 mM NaCl
Storage Temperature: -80ºC
Alternative Names: Tau aggregate, tau protein, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Aggregate, Paired Helical Filiment-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid tau protein fragment, Tuncated Tau
Research Areas:: Alzheimer’s Disease, Axon Markers, Cell Markers, Cell Signaling, Cytoskeleton, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Tangles & Tau

Product manufactured in Canada by StressMarq.


Scientific Background

Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65. Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrallary tangles containing paired helical filaments (PHFs). Brain-specific tau isoforms vary in the number of N-terminal inserts and C-terminal repeat domains due to alternative splicing of exons; only the shortest isoform of tau, 0N3R, is expressed in the fetal brain during neurogenesis. Three-repeat (3R) isoforms have been shown to be more prone than four-repeated (4R) isoforms to form oligomers in vitro. The Beta-sheet core of Tau 0N3R fibrilized using heparin differs from all other tau fibril structures known to date.


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Documents

Product Manual


Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations