Human Recombinant Alpha Synuclein S87N Mutant Monomers


The Human Recombinant Alpha Synuclein S87N Mutant Monomers are for research use only and not to be used for diagnostic procedures. Contact us for bulk pricing.

SKU: SPR-499B Categories: ,

Human Recombinant Alpha Synuclein S87N Mutant Monomers

Human Recombinant Alpha Synuclein S87N Mutant Monomers are For Research Use Only

Size: 100 ug
Species: Human
Expression System: E. coli
Buffer: 1X PBS pH 7.4
Storage Temperature: -80ºC
Alternative Names: MAPT, 2N4R, Tau40 neurofibrillary tangle protein, paired-helical filament, PHFs, SNCA, NACP, PARK1, asyn, alpha-synuclein, pre-formed fibril, PFFs, mixed fibrils
Research Areas:: Alzheimer’s Disease, Neurodegeneration, Neuroscience, Parkinson’s Disease, Synuclein, Tangles & Tau, Multiple System Atrophy

Product manufactured in Canada by StressMarq.

Scientific Background

Human alpha synuclein S87N mutant (HuS87N) has Ser87 mutated to the equivalent mouse residue Asn87, effectively making it a human-mouse chimeric protein. Despite sequence differences at only seven residues, or 5% of the total 140 amino acids, the aggregation rate of wild-type mouse α-syn (MsWT) is faster than wild-type human α-syn (HuWT) in vitro. In wild-type mouse models, MsWT fibrils are more efficient than HuWT fibrils at inducing pathology of endogenous mouse α-syn. A53T or S87N substitutions in human α-syn substantially accelerate fibrilization rates in vitro. Chimeric HuS87N fibrils show enhanced pathogenicity to wild-type mouse neurons, greater than HuWT, HuA53T, and MsWT fibrils. HuS87N fibrils can be used as a more human-like alternative to MsWT fibrils to induce equivalent or greater endogenous α-syn seeding and pathology in wild-type mice.

Related Products

Active Human Recombinant Gamma Synuclein Protein Preformed Fibrils (Type 1)

Active Human Recombinant Truncated Tau Fragment (AA297-391) (dGAE) Protein Monomer


Product Manual

Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations