Human Recombinant Alpha Synuclein S87N Mutant Monomers
Human Recombinant Alpha Synuclein S87N Mutant Monomers are For Research Use Only
Size: 100 ug
Expression System: E. coli
Buffer: 1X PBS pH 7.4
Storage Temperature: -80ºC
Alternative Names: MAPT, 2N4R, Tau40 neurofibrillary tangle protein, paired-helical filament, PHFs, SNCA, NACP, PARK1, asyn, alpha-synuclein, pre-formed fibril, PFFs, mixed fibrils
Research Areas:: Alzheimer’s Disease, Neurodegeneration, Neuroscience, Parkinson’s Disease, Synuclein, Tangles & Tau, Multiple System Atrophy
Product manufactured in Canada by StressMarq.
Human alpha synuclein S87N mutant (HuS87N) has Ser87 mutated to the equivalent mouse residue Asn87, effectively making it a human-mouse chimeric protein. Despite sequence differences at only seven residues, or 5% of the total 140 amino acids, the aggregation rate of wild-type mouse α-syn (MsWT) is faster than wild-type human α-syn (HuWT) in vitro. In wild-type mouse models, MsWT fibrils are more efficient than HuWT fibrils at inducing pathology of endogenous mouse α-syn. A53T or S87N substitutions in human α-syn substantially accelerate fibrilization rates in vitro. Chimeric HuS87N fibrils show enhanced pathogenicity to wild-type mouse neurons, greater than HuWT, HuA53T, and MsWT fibrils. HuS87N fibrils can be used as a more human-like alternative to MsWT fibrils to induce equivalent or greater endogenous α-syn seeding and pathology in wild-type mice.