Tau-352 (fetal 0N3R) Pre-formed Fibrils (PFFs)
Tau-352 (fetal 0N3R) Pre-formed Fibrils are For Research Use Only
Size: 100 ug
Expression System: E. coli
Buffer: 10 mM Hepes pH 7.4, 100 mM NaCl
Storage Temperature: -80ºC
Alternative Names: Tau aggregate, tau protein, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Aggregate, Paired Helical Filiment-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid tau protein fragment, Tuncated Tau
Research Areas:: Alzheimer’s Disease, Axon Markers, Cell Markers, Cell Signaling, Cytoskeleton, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Tangles & Tau
Product manufactured in Canada by StressMarq.
Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65. Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrallary tangles containing paired helical filaments (PHFs). Brain-specific tau isoforms vary in the number of N-terminal inserts and C-terminal repeat domains due to alternative splicing of exons; only the shortest isoform of tau, 0N3R, is expressed in the fetal brain during neurogenesis. Three-repeat (3R) isoforms have been shown to be more prone than four-repeated (4R) isoforms to form oligomers in vitro. The Beta-sheet core of Tau 0N3R fibrilized using heparin differs from all other tau fibril structures known to date.