SNCA Protein Pre-formed Fibrils ATTO 594
The SNCA Protein Pre-formed Fibrils ATTO 594 is For Research Use Only
Specificity: N/A
Species: Human
Expression System: E. coli
Buffer: PBS pH7.4, 0.09% Azide
Storage Temperature: -80ºC
Alternative Names: Active Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils: ATTO 594, Active Alpha synuclein PFFs, Active Alpha synuclein aggregates, Alpha synuclein PFF, Active Alpha synuclein protein aggregates, Active Alpha synuclein aggregates, Active Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson’s disease familial 1 Protein, Active Alpha synuclein protein seed, ATTO 594 conjugated alpha synuclein, ATTO labelled alpha synuclein fibrils
Product manufactured in Canada by StressMarq.
Scientific Background
Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson’s disease. Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
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