Anti-FGFR-3 Autoantibodies ELISA
The Anti-FGFR-3 Autoantibodies ELISA is For Research Use Only
Size: 1×96 wells
Sensitivity: 0.8 Units/ml
Dynamic Range: 1.25 U/ml and 40 U/ml
Incubation Time: 3 hours 20 minutes
Sample Type: Serum
Sample Size: 100 µL
Alternative Names: Fibroblast growth factor receptor 3, CD333
Controls Included
Assay Background
Fibroblast growth factor receptor 3 (CD333) is a protein that in humans is encoded by the FGFR3 gene. Fibroblast growth factor receptor 3 interact with FGF8 and FGF9. FGFR3 inhibitors are in early clinical trials as a cancer treatment for urothelial carcinoma. FGFR3 antibodies have been reported in sensory neuropathy.
Assay Principle
The anti-FGFR3-antibody-EIA is an antibody screening test. The FGFR3 protein has been pre-coated onto a microtiter plate. During the first incubation the anti-FGFR3-antibodies of the samples are immobilized on the plate. The autoantibodies are detected with a POD labeled antihuman IgG antibody. In the following enzymatic substrate reaction the intensity of the color correlates with the concentration and/ or avidity of anti-FGFR3-antibodies.
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