Risankizumab (SKYRIZI) ELISA Assay Kit
The Risankizumab (SKYRIZI) ELISA Assay Kit is For Research Use Only
Size: 1 x 96 wells
Calibrator Range: 10 – 640 ng/mLL
Sample Size: 100 uL
Sample Type: Serum and Plasma
Incubation Time: 2 hours 30 minutes
Assay Background
Risankizumab is a humanized immunoglobulin (Ig) G1 monoclonal antibody that specifically targets the p19 subunit of interleukin (IL)-23, thereby inhibiting IL-23-dependent cell signaling. Risankizumab was approved by the U.S. FDA for treatment of moderate-to-severe plaque psoriasis in April 2019, and in vitro, has been more potent in inhibiting IL-23 signalling than other drugs performing in the same IL-23 complex.
Assay Principle
IL-23A Protein is pre-coated onto microwells. Samples and standards are pipetted into microwells. Risankizumab present in the sample is bound by the protein. Then, an Anti-Human IgG conjugated to HRP is pipetted and incubated. After washing microwells, in order to remove any non-specific binding, the ready to use substrate solution (TMB) is added to microwells and color develops proportionally to the amount of Risankizumab in the sample. Color development is then stopped by addition of stop solution. Absorbance is measured at 450 nm.
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