Recombinant SARS-CoV-2 Protein (ACE2) Extracellular Domain
The Recombinant SARS-CoV-2 Protein (ACE2) Extracellular Domain is For Research Use Only
Description: Recombinant Human Angiotensin-converting enzyme 2 (ACE2)-Extracellular Domain, NCBI Accession Number: NM_021804.3
Expression System: HEK293 cells
Tag: HIS Tag C-Terminus
Purification: Affinity chromatography
Extinction Coefficient: 152220 M-1.cm-1 Abs 0.1% (=1 g/l) 2.171 assuming all pairs of Cys residues form cystines
Predicted Molecular Weight: 70.1 kDa
SDS Page: Approx. 75 kDa
Concentration: 0.35 mg/ml
Purity: >95% by SDS PAGE
Endotoxins: Negative on cell-based assay
Activity: Recognized by Recombinant Receptor Binding Domain of Spike protein in binding assay
Stability and Storage: Store at -20°C. Avoid repeated freeze-thaw cycles. Stable one week at 2 to 8°C after reconstitution under sterile conditions. Stable 12 months -20°C to -80°C after reconstitution under sterile condition.
Angiotensin-converting enzyme 2, or ACE2, is a protein bound to the plasma membrane of lungs, arteries, heart, kidney, and intestines cells. ACE2 plays an important role in the renin-angiotensin-aldosterone system (RAAS), and a major physiological role in the regulation of the heart, kidney and blood pressure.
ACE2 is also the cellular receptor for Severe Acute Respiratory Syndrome – coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is causing the coronavirus disease 2019 (COVID-19) pandemic.