Mouse Soluble alpha-Klotho ELISA
Mouse Soluble alpha-Klotho ELISA Developed and Manufactured by Immuno-Biological Laboratories Co., Ltd
Size: 1×96 wells
Sensitivity: 18.06 pg/mL
Standard Range: 78.13 – 5000.0 pg/mL
Incubation Time: 2 hours
Sample Type: Urine
Sample Size: 100 µl
Assay Background
“α-klotho” was identified as an extremely down-regulated gene in the genetically-modified mouse of which phenotype is very similar to various symptoms of human aging. Then, the sequences of α-klotho genes have been identified in various species including humans based on the one of mouse. α-Klotho protein is a 130 kDa, one-transmembrane protein and its expression is confirmed in the kidneys and the parathyroid glands. In recent years, it has become clear that α-Klotho is an important molecule within a living organism regulating the metabolism of mineral such as calcium and phosphorus. Therefore, it is considered that, in α-klotho mouse, early aging-like symptoms are induced by impaired mineral homeostasis caused by decreased expression of α-Klotho.
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