Mouse MPO ELISA Kit
Myeloperoxidase (MPO) is a heme-containing enzyme expressed primarily in cells of the myeloid lineage and is abundantly present in the azurophilic granules of polymorphonuclear neutrophils. MPO plays an important role in the antimicrobial defense response by catalyzing the production of hypochlorous acid (HOCl), a potent oxidant, during the phagocytic destruction of engulfed microorganisms and foreign particles. MPO is rapidly released from activated neutrophils and contributes to the regulation of inflammatory and oxidative processes.
In research settings, MPO is widely studied as a biomarker of neutrophil activation, inflammation, and oxidative stress. Researchers investigate MPO activity and levels in experimental models of inflammatory and immune-mediated conditions, including atherosclerosis, pulmonary disease, neurodegenerative disorders, and other diseases involving neutrophil activation. Measurement of MPO can help characterize inflammatory responses and investigate mechanisms involving neutrophil-mediated tissue injury.
In clinical settings, MPO has been studied as a biomarker in several inflammatory and cardiovascular conditions. Elevated MPO levels or activity have been associated with conditions such as atherosclerosis, lung disease, Alzheimer’s disease, and multiple sclerosis. Autoantibodies directed against MPO are also associated with certain autoimmune vasculitides, including granulomatosis with polyangiitis (formerly known as Wegener’s granulomatosis). Measurement of MPO and MPO-specific antibodies can provide information about inflammatory and immune responses and support research into disease mechanisms and potential therapeutic targets.
This Mouse MPO ELISA Kit is manufactured in Netherlands by Hycult Biotech.
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