IGFBP-2 ELISA Assay Kit
The IGFBP-2 ELISA Assay Kit is For Research Use Only
Size: 1×96 wells
Sensitivity: 0.2 ng/ml
Standard Range: 2 – 80 ng/ml
Incubation Time: 2 hours
Sample Type: Serum, Plasma, Biological Fluids, Cell Culture
Sample Size: 15 µL
Manufactured by Mediagnost
Assay Background
Insulin-like growth factors (IGFs) regulate the proliferation, differentiation, apoptosis, cell adhesion and metabolism in various tissues and cell types. The IGF-I, which is produced mainly in liver under the influence of growth hormone (GH), regulates as hormone the linear growth of the bones and the process of sexual maturity, while IGF-II is mainly a growth factor of fetal tissue. The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6). IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood. IGFs, especially tumor typical pro-IGF-forms and hormones regulate the expression of IGFBP-2, GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism.
IGFBP-2 is an unglycosylated polypeptide of 31.3 kDa, which forms binary IGF-complexes and shows no circadian rhythm in the circulation. The serum concentration of IGFBP-2 increases in fasting, after major surgery and after trauma, but the increase of the concentration is most intensive in malignant diseases. The correlation of the IGFBP-2 level to the degree of progression is a striking feature in various tumor types as is the normalization of the IGFBP-serum levels after remission. The IGFBP-2 concentration is age-dependent in blood.
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