Human [Leu24] IGF-I


The Eagle Bioscience’s Human [Leu24] IGF-I is for research use only and not to be used in diagnostic procedures.

SKU: ZU100B Categories: , ,

Human [Leu24] IGF-I

The Eagle Bioscience’s Human [Leu24] IGF-I is for research use only and not to be used for diagnostic procedures.

Product Specifications


IGF-I is produced in E.coli using a patented expression system and the IGF-I is correctly folded and purified by several chromatography steps to yield Receptor Grade IGF-I.


Human [Leu24] insulin-like Growth Factor-I ([Leu24] IGF-I) is an analogue of human IGF-I which has a Leucine substitution in place of Tyrosine at position 24 of the sequence. [Leu24] IGF-I has normal binding to acid-stripped human serum binding proteins but has reduced binding to the type 1 IGF receptor and to the insulin receptor compared to IGF-I. It is a useful analogue for studying the relative effects of IGF-I through the type 1 receptor and IGF binding proteins. 

  • Purity: >95 % (as determined by HPLC analysis)
  • Quantity: 100 µg
  • Molecular Weight: 7599 daltons – confirmed by Mass Spectrometry
  • N-terminal sequence analysis of recombinant product: Analysis of 5 residues
  • Biological Activity: Stimulation of protein synthesis in rat L6 myoblasts (ED50 < 100 ng/ml) IGF type 1 receptor binding assay (ED50 > 100 ng/ml)
  • Endotoxin (LAL): <0.1 EU/ug
  • Storage/Stability: At least 2 years at 2-4°C (lyophilized)
  • Appearance: White Powder
  • State: Dried from 0.1 M acetic acid under dry nitrogen at a slight vacuum (-25kPa)

Related Products

Rodent IGF-I ELISA Assay
Insulin-Like Growth Factor Binding Protein-1 ELISA
Biotinylated Human Des IGF-1

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Product Manual

Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

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