Human IGF-I (Media Grade)

$790.00$2,380.00

The Eagle Bioscience’s Human IGF-I (Media Grade) is for research use only and not to be used for diagnostic procedures.

SKU: IM Categories: ,

Human IGF-I (Media Grade)

The Eagle Bioscience’s Human IGF-I (Media Grade) is for research use only and not to be used for diagnostic procedures.


Product Specifications

Source:

IGF-I is produced in E.coli using a patented expression system and the IGF-I is correctly folded and purified by several chromatography steps to yield Receptor Grade IGF-I.

Description:

Human insulin-like growth factor-I (IGF-I) is a single chain 70 amino acid polypeptide that shares structural homology with insulin and human IGF-II. IGF-I plays a critical role in growth, differentiation, and development via autocrine, paracrine and endocrine mechanisms. It is a mitogen and also has effects on cell migration and differentiation. IGF-I binds to the type I IGF receptor and most of its actions are probably mediated through inducing signal transduction via this receptor. IGF-I also binds to each of the six IGF binding proteins (IGFBPs). This binding also regulates the biological function of IGF-I. IGF-I is highly conserved across species which suggests an important role for the peptide. Human IGF-I is present in high concentrations in normal adult human serum in a complex with IGFBP-3 and the acid-labile subunit (ALS) and mediates many of the actions of Growth Hormone. IGF-I is a regulator of metabolism and is also implicated in the pathophysiology of cancer, diabetes, and obesity. 

  • Purity: >85 % (as determined by HPLC analysis)
  • Quantity: 1 mg, 5mg
  • Molecular Weight: 7649 ± 2 Daltons- confirmed by Mass Spectrometry
  • N-terminal sequence analysis of recombinant product: 5 residues >95% single sequence
  • Biological Activity: Proliferation of Chinese hamster ovary (CHO) cells (EC50 < 350 ng/ml)
  • Endotoxin (LAL): <0.1 EU/ug
  • Storage/Stability: At least 2 years at 2-8°C (lyophilized)
  • Appearance: White Powder
  • State: Dried from 0.1 M acetic acid under dry nitrogen at a slight vacuum (-25kPa)

Related Products

Receptor Grade IGF-I Recombinant Protein
Human Arg3 IGF-1 Biotin
IGF-I ELISA Assay

Documents

Product Manual


Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations