Human GFRa-2 Chicken Polyclonal Antibody
The Human GFRa-2 Chicken Polyclonal Antibody is For Research Use Only
Immunogen: Human GFRa-2
Uniprot ID: O00451
Alternative Names: GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2
Clonality: Chicken polyclonal
Reactivity: Human GFRa-2, doesn’t cross-react with hGFRa-1, hGFRa-3, hGFRa-4
Application: ELISA, WB, IF
Purification: GFRa-2 affinity purified
Buffer: Concentrated ammonium sulphate in PBS pH 7.4
Concentration: 1 mg/ml
Unit Size: 100 µg
Related Products: Mono- and polyclonal antibodies to human growth factors and neural growth factor receptors.
Shipping: This product is shipped in non-frozen liquid form in ambient conditions.
Storage: Store at +4°C upon receipt. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use
Protocol: Western immunoblotting, recommended dilution 1:5 000 to 1:10 000; ELISA: 1:128 000 to 160 000, IF 1:500 to1:1000. Polyclonal antibody working titer has to be established practically for each particular antigen and assay format.
Background: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRa-2 is a member of the GDNF receptor family. It is a glycosylphosphatidyl-inositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NRTN compared to its other family member, GDNF family receptor alpha 1. https://www.ncbi.nlm.nih.gov/gene/2675.
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Product Developed and Manufactured by Icosagen