HCC-REAAD ErbB3 ELISA Assay
The HCC-REAAD ErbB3 ELISA Assay is For Research Use Only
Size: 1×96 wells
Sensitivity: 0.3 RU
Standard Range: 0.3-0.7 RU
Incubation Time: 1.75 hours
Sample Type: Serum, plasma
Sample Size: 100 µl
Alternative Names: Hepatocellular Carcinoma -REcombinant Antigen-Antibody Detection, Receptor tyrosine-protein kinase erbB-3, HER3, Human Epidermal Growth Factor Receptor 3
Liver Cancer is the sixth most common cancer malignancy in the world with 83% of cases occurring in less developed countries . Liver Cancer is the second leading cause of cancer death worldwide. The highest estimated mortality rates are in Eastern and South-Eastern Asia [1,3]. Hepatocellular Carcinoma (HCC) is the most common type of liver cancer, accounting for at least 70% of the total liver cancer cases . HCC was once prevalently only in Southeast Asia and Africa due to dietary intake of aflatoxin contaminated food grains. However, in recent years, an increase of HCC incidences is discovered in Europe and United States . Higher levels of ERBB3 proteins were detected in patients with HCC as compared to non-HCC patients .
HCC-REAAD™ ERBB3 ELISA uses two layers of antibodies (i.e. capture and detection antibody) targeting at two different antigenic epitopes expressed by human ERBB3 protein capable of binding to the respective antibody to semi-quantify the level of human ERBB3 protein. The test uses an arbitrary unit of measurement known as REAAD™-units (RU).
HCC-REAAD™ ERBB3 ELISA incorporating the use of algorithm, is intended as an aid for the diagnosis of hepatocellular carcinoma. Combining the levels of ERBB3 protein determined using HCC-REAAD™ ERBB3 ELISA and levels of AFP (e.g. Elecsys AFP) together with the age of the individual into a mathematical algorithm (binary logistic regression) enables the early detection of HCC as comparing to using AFP alone. The algorithm is a useful tool to determine patients’ HCC risk level.
All data from these assays, however at best offer supplementary information to clinicians and act as an aid to diagnosis only. It is therefore important that a diagnosis is made in conjunction with other recommended clinical investigations.
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Product manufactured by Restalyst.