Bovine Betacellulin

$170.00

The Eagle Bioscience’s Bovine Betacellulin is for research use only and not to be used for diagnostic procedures.

SKU: ARU100 Categories: ,

Bovine Betacellulin

The Eagle Bioscience’s Bovine Betacellulin is for research use only and not to be used for diagnostic procedures.


Product Specifications

Source:

Produced in E.coli using a patented expression system.

Description:

Bovine Betacellulin (BTC), a member of the EGF family, is an 80 amino acid heparin-binding protein. Like other members of the EGF family, it is synthesized as a transmembrane precursor. The soluble cytokine, containing one EGF structural motif, is released by proteolytic cleavage. BTC can bind to the EGF receptor (ErbB-1) which then dimerizes with another member of the ErbB receptor family to signal through the tyrosine kinase pathway. BTC is a potent mitogen for Balb/c 3T3 fibroblasts, retinal pigment epithelial cells and vascular smooth muscle cells and is the only member of the EGF family to stimulate insulin secretion in pancreatic beta cells.

  • Purity: >95 % of the two BTC variants (by SDS-PAGE)
  • Quantity: 100 µg
  • Molecular Weight: Theoretical molecular weight is 8995 daltons
  • N-terminal sequence analysis: Analysis of 5 residues demonstrating and equal mixture of [Gly1] bovine betacellulin (50%) and Des [1-4] bovine betacellulin
  • Biological Activity: Stimulation of cell growth in Balb/c 3T3 fibroblasts (ED50 < 10 ng/ml)
  • Endotoxin (LAL): <0.1 EU/ug
  • Storage/Stability: At least 2 years at 2-4°C (lyophilized)
  • Appearance: White powder freeze-dried from 0.05M acetic acid/0.05% (v/v) trifluoroacetic acid and stored under nitrogen at a slight vacuum.

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Documents

Product Manual


Please note: All documents above are for reference use only and should not be used in place of the documents included with this physical product. If digital copies are needed, please contact us.

Product Citations