is CNP?

        CNP stands for C-type natriuretic peptide and it is
        derived from a preprohormone of 126 amino acids and a prohormone of 53 amino
        acids. CNP was originally found in the
        central nervous system in much greater concentrations than ANP or BNP. CNP
        is produced by cardiac tissue, but is expressed primarily in the brain,
        pituitary gland, vascular endothelium, kidney and female reproductive tract. It
        has been discovered that it is produced in the vascular endothelial cells and after
        secretion of CNP from these endothelial cells, it is regulated by cytokines and
        growth factors.

        Unlike ANP and BNP, CNP has a very insignificant role
        in natriuretic and diuretic processes. The
        physiological role of CNP is not only studied in cardiac disease, but also in
        bone developmental biology, bone research, renal diseases, embryonic
        developmental research, and vascular diseases. In past studies, it has been
        found to play an important paracrine regulatory role in the
        vasculature and involvement in neural control.

        Biochemical Structure of CNP:

        CNP produces 22 and 53 amino acid fragments.
        Unlike ANP and BNP, CNP terminates in the second cysteine residue, lacking a
        further C-terminal extension.

        What is NTproCNP?

        NT-proCNP is the amino-terminal peptide derived from the cleavage of the prohormone proCNP. It is an equimolar product of CNP biosynthesis and is easily measured in plasma. NTproCNP is not subject to clearance pathways and it is found in the circulation at 20- to 50-fold higher concentrations than the biologically active forms of CNP. 

        Why Measure NTproCNP?

        NTproCNP is considered to be a reliable and stable marker for measuring
        CNP biosysthesis. Studies have revealed
        that there is a high serum CNP concentration in critically ill subjects or individuals
        who have undergone trauma. NT-proCNP has
        been correlated to biomarkers of organ dysfunction and has been associated with
        inflammatory and metabolic pathways.
        Therefore, it has been recently been proposed as a novel biomarker for
        predicting sepsis in traumatized patients.

         Indications for CNP:

        • Vascular Disease
        • Diabetes
        • Skeletal Development
        • Sepsis
        • Renal Disease


        1. Clerico A et al. “Thirty years of the heart as an endocrine organ: physiological role and clinical utility of cardiac natriuretic hormones.” Am J Physiol Heart Circ Physiol 2011; 301: H12-H20.
        2. Hoffman et al. “Prognostic Value of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients With Severe Sepsis.” Circulation; 2005:112:527-534.
        3. Koch, A. et al. “Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients.” Critical Care 2011, 15:R45 doi:10.1186/cc10007.
        4. Moro, Cedric et al. “Natriuretic Peptides: New Players in Energy Homeostasis.” Diabetes 2009; 12: 2726-2728
        5. Nazario, B et al. “Atrial and Brain Natriuretic Peptides Stimulate the Production and Secretion of C-type Natriuretic Peptide from Bovine Aortic Endothelial Cells.” Journal of Clinical Investigation 1995 Mar; 95(3): 1151–1157. 
        6. Olney, Robert et al. “Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) predicts height velocity in healthy children.” Clin Endocrinol (Oxf). 2012 Sep; 77(3): 416–422.
        7. Schreibe, Donald et al. “Natriuretic Peptides in Congestive Heart Failure.” Medscape 2012: Jan 10.
        8. Suzuki, T et al. “The Role of the Natriuretic Peptides in the Cardiovascular System.” Cardiovascular Research 2001; 51: 489–494.

        Related Resources Citing EagleBio Kits:

        1. Stanek, B. et al. “Prognostic evaluation of neurohumoral plasma levels before and during beta-blocker therapy in advanced left ventricular dysfunction” Journal of American Cardiology 2001; 38: 436-442.

        Related Kits:

        NT-proCNP ELISA Assay Kit

        proANP ELISA Assay Kit

        BNP Fragment (Nt-proBNP 8-29) ELISA Assay Kit

        Cardiovascular Assay Kits

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