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Testosterone: Why Higher Levels are Connected to Prostrate Enlargement

A recent study at the University of California – Santa Barbara (UCSB) focused on testosterone levels in a cohort of men in the US and compared results to previous research on a group of 350 adult males in Tsimane,Bolivia where researchers examined the prevalence of Benign prostatic hyperplasia (BPH)(aka. prostrate enlargement). BPH is one of the most prevalent diseases among aging men in the US. The causes and underlying factors that contribute to this disease have not yet been identified, thus the reason for this study.

It has been explained in recent publicationsthat men in Tsimane have 30% lower testosterone levels because of environmental (numerous parasites and pathogens) and lifestyle factors (hunting, fishing,foraging: causing the need to maintain testosterone in order to maintain muscle mass). Antropologists from UCSB believe that increased levels of testosterone compromises the immune system in order to keep it low in environments where parasites and pathogens are rampant. It was discovered that the cases of advanced prostrate enlargement were nonexistent.

Because men in the US have a higher level of testosterone and their levels decrease with age, there has been a trend to supplement this decline with replacement therapy. It is believed that interfering with Mother Nature may not be the best choice and we are left to wonder, is this what is causing the increase in prostrate cancer and other diseases? Read More

image above from:https://www.ia.ucsb.edu/

Related Kits:

Free Testosterone ELISA Assay

Testosterone ELISA Assay Kit

Testosterone Saliva ELISA Assay Kit

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EagleBio Spotlight: Free Testosterone

EagleBio’s Free Testosterone ELISA: Product Highlights

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New Study Using EagleBio’s Histamine ELISA Kit

by Eagle Biosciences

A recent study was conducted at Tulane University in New Orleans, Louisiana using EagleBio’s Histamine ELISA, a kit designed for the quantitative determination of histamine in plasma, urine, and cell culture. This assay is part of our Immunology Assay Kit line which is comprised of a unique,versatile set of products for a variety of applications, research, and fields of study. Check the product pages for full details on the kit or view the links below to find a new publication referencing our Histamine ELISA.

New Publication:

Oxidized Low-Density Lipoprotein Contributes to Atherogenesis via Co-activation of Macrophages and Mast Cells

Study Summary:

Static and microfluidic flow experiments were performed to investigate the number of adherent monocytes on vascular endothelium that are activated by supernatants of oxLDL-treated macrophages and mast cells or directly by oxLDL. Based on results from this study, it was discovered that the degranulation of mast cells during allergy attacks could lead to increases in the histamine concentration near or inside atherosclerotic lesions. In fact, the amount of histamine that is released can be significantly more than that produced by oxLDL-activated mast cells. Therefore, this suggests that allergy attacks can cause weakening of the endothelium already exposed to TNF-α and histamine from oxLDL-activated macrophages and mast cells.

The final conclusion from this study was that individuals with allergy or asthma who have an elevated amount of histamine in tissues are in fact at very high risk for atherosclerosis and cardiovascular disease if they also have a lipid-rich diet. Other recent studies support this data and point out that allergy and asthma contribute to the development of atherosclerosis.

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EagleBio’s Latex Allergen FITkit® ELISAs: Product Highlights

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Latex Allergen FITkit® ELISAs

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EagleBio’s Monthly Promotions- ADMA ELISA Assay Kit

by Eagle Biosciences

30% Discount on our:

ADMA ELISA Assay Kit

Mouse / Rat ADMA ELISA

ADMA / Arginine ELISA Assay Kit

SDMA ELISA Assay Kit

Homoarginine ELISA

This promotion is good through May 31st, just use code below when ordering.

PROMOTIONAL CODE: ADM0630

Related Products:

Cardiovascular Assay Kits

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EagleBio Biomarker Spotlight: ADMA

New Listing of ADMA Assay Publications

August 4, 2011: Eagle Biosciences Introduces ADMA ELISA Product Line

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Promising New Target for the Treatment of Chronic Pain

by Eagle Biosciences

A recent study at the University of Texas at Dallas focused on following the sequence of pain impulses traveling from the brain to the spinal cord in mice. These researchers were interested in learning more about chronic pain as well as the intricate biological processes and chemicals that are involved. The goal of this research was to better understand the mechanisms that cause and contribute to chronic pain in order to point to more effective treatments. The results of this study revealed that by removing a collection of neurons called A11 that contain dopamine, chronic pain was selectively diminished.

More than 100 million people in the US suffer from chronic pain and it is an extremely costly and debilitating medical condition. This study and its findings bring promise to new future target medicines. Read More

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Dopamine ELISA Assay Kit

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Dopamine Sensitive ELISA

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Adrenaline, Noradrenaline & Dopamine ELISA Assay Kit

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New Study Referencing EagleBio’s Serotonin ELISA Assay Kit

by Eagle Biosciences

EagleBio continuously has researchers publishing new literature referencing our kits for a variety of our product lines. A recent study was conducted by Johns Hopkins University School of Medicine utilizing a kit from our Neurobiology Assay Kit line. The Neurobiology Assay Kit line offered Eagle Biosciences provides a comprehensive array of sensitive tools to measure catecholamines and numerous neuroscience-related analytes on various types of samples. Check the product pages for full details on the kit or view the links below to find a new publication referencing our Serotonin ELISA Assay Kit.

New Publication:

Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART

Related News:

EagleBio Assay Kits in Several New Publications

January 21, 2015- Eagle Biosciences Shares Some New Publications Across Multiple EagleBio Assay Kit Product Lines

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Major Breakthrough for Alzheimer’s: Treatment in the Horizon

by Eagle Biosciences

The amazing, groundbreaking results from a recent study conducted by researchers at the University of California, San Diego School of Medicine and Cenna Biosciences, Inc. could ultimately translate into human treatment. They have discovered compounds that block beta amyloids in mice. In fact, this new method has the potential to completely halt the disease all together which other methods in the past have not been able to do. Other drugs and research from previous studies have targeted cleaving beta amyloid from its larger precursor protein but in the process these drugs have cleaved other proteins as well causing undesirable effects on the body.

The accumulation and build up of amyloids plaques have been believed to cause the irreversible damage in the brain that affects cognitive function and other symptoms associated with Alzheimer’s. Therefore, a compound that directly attacks amyloids is key to successful treatment and this new compound (P8 Compound) does just that. Read More

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Neurobiology Assay Kits

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EagleBio’s Free Testosterone ELISA: Product Highlights

by Eagle Biosciences

Eagle Biosciences’ Steroid Assay Kit line offers an array of interesting and sensitive assays for different hormone analytes and research needs. OurFree Testosterone ELISA is a top seller at Eagle Biosciences and continues to be a valuable tool for researchers in various fields of study. It offers a variety advantages over other kits in the market and it is recognized for its ability to measure the free or unbound fraction of serum testosterone with unsurpassed sensitivity and accuracy.

Why Measure Free Testosterone with EagleBio’s Kit?

1. Excellent Specificity: 100% specificity to free testosterone

2. Unsurpassed Sensitivity: lowest detectable concentration is 0.04 pg/ml

3. Quick and Simple Test Results: < 2hours

4. Easy to Automate

Our Free Testosterone ELISA Kit is a 2nd generation assay and is more sensitive, accurate, and precise than the previous versions with less interference of matrix effects in samples. It provides an excellent correlation to free androgen index (total Testosterone/SHBG) and is an effective means to truly capture the unbound or free testosterone in each sample thereby estimating the physiologically bioactive hormone.

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Testosterone ELISA Assay Kit

Testosterone Saliva ELISA Assay Kit

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Eagle Biosciences Shares New Literature Utilizing Select Hormone Assays

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Human Embryo Editing: The Controversy and Some Reasons it Needs Further Research

by Eagle Biosciences

ivf-egg-fertilize-101005-02

A recent study by Chinese scientists involving the attempt to modify the genes of human embryos has sparked some controversy and some concern by other scientists in the field. The process they used was a genetic engineering technique called CRISPR (clustered regularly interspaced short palindromic repeat) to remove a faulty gene and replace it with a healthy one in human embryos. The original plan and hope for such a process may hold extraordinary promise for both basic research and clinical applications. However, DNA repair mechanisms have not been studied enough and are not fully understood, thus it is difficult for researchers to predict how the genome will be affected and what mutations could occur. Looking at the bigger picture beyond the potential power of treating diseases, the unpredictable effects on future generations places this process in jeopardy of being defined as unethical and dangerous. Read More

What do you think?

image above from www.livescience.com

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EagleBio Spotlight: Free Testosterone

by Eagle Biosciences

Testosterone
is a steroid hormone from the
androgen group and is predominantly secreted in the testes of males and the
ovaries of females however, there is a small amount of this hormone that is secreted
by the adrenal glands. Testosterone is
the primary male sex hormone as well as an anabolic steroid and it plays key
roles for the health and well-being of both males and females.

Only a small percentage of circulating testosterone
exists as unbound or free testosterone. In fact, testosterone circulates 98%
protein-bound (54% with low affinity to albumin and other proteins, and 44%
with high affinity to SHBG) with only 2% circulating as free testosterone. The
portion which is unbound, referred to as free testosterone, is considered the
component that has the ability to enter cells and in turn, has androgenic
effects. Thus, for these reasons it is proposed that free testosterone will
relate to the biological effect on tissue more than the total testosterone.

Reasons to
Measure Free Testosterone

It is important to measure Free Testosterone for detecting
and monitoring various conditions and diseases that affect both men and women.
Free testosterone is responsible for sexual traits and health problems can
result from elevated or decreased levels of this hormone. As mentioned above, the measurement of the
free or unbound fraction of serum testosterone provides a means of estimating
the physiologically bioactive hormone.

Free Testosterone has been associated
with many diseases and disorders/conditions

Males:

Primary and secondary hypogonadism- A failure of the gonads, testes in men and ovaries in
women, to function properly (i.e. primary– direct failure of gonad and secondary–
indirect failure of gonad due to problem in the hypothalamus or the pituitary
gland)

Delayed or advanced puberty

Impotence

Loss of sex drive

Bone loss

Infertility

Cushing Syndrome

Females:

Hirsutism– excessive
hair

Virilization-
biological development of sex differences- changes that make the female body
different from a male body- masculization occurs) due to tumors

Polycystic ovaries –Polycystic ovary syndrome (PCOS)
–a condition discerned by infertility, lack of menstruation, acne, and excessive
hair growth, particularly on the face

Androgenital syndromes

Cushing Syndrome

References:

1. Alan, Carolyn et. al. “Age-related changes in testosterone and the role of replacement therapy in older men.” Clinical Endocrinology. 2004; 60:6:653–670.

2.Rosner W, Auchus RJ, Azziz R, et al. “Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society Position Statement”. J Clin Endocrinol Metab. 2007;92:405-413.

3. Sodergard, R et al. “Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature”. Journal of Steroid Biochemistry. 1982; 16, 801–810.

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Free Testosterone ELISA Assay Kit

Testosterone ELISA Assay Kit

Testosterone Saliva ELISA Assay Kit

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Eagle Biosciences Shares New Literature Utilizing
Select Hormone Assays

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Eagle Biosciences Shares New Literature Utilizing Select Hormone Assays

by Eagle Biosciences

Eagle Sciences offers a wide range of hormone assays that are the best kits available worldwide. Listed below are some new publications from scientists who have successfully completed their studies utilizing our: Estradiol ELISA, Testosterone ELISA, Progesterone ELISA, and kits from our Steroid Assay Kit Line.

Estradiol ELISA Assay Kit,Testosterone ELISA Assay Kit, Progesterone ELISA Assay Kit:

New Publication:

Investigation of sex reversal in layer chickens in Bangladesh

Cortisol Saliva ELISA Assay Kit:

New Publication:

Circadian rhythms of ewes suckling singletons versus twins during the second week of lactation

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Steroid Assay Kits

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April 1, 2011: Eagle Biosciences Introduces High Sensitive Steroid Saliva ELISA Kits