Vanin-1 (VAN1) is an anchored protein that catalyzes the hydrolysis of pantetheine to pantothenic acid (vitamin B5) and cyteamine. VAN1 has a broad tissue expression with the highest levels being observed in kidney tubular epithelial cells. The GPI anchor of VAN1 can be cleaved by a yet unknown mechanism, resulting in VAN-1 being shed into the extracellular space.
Vanin-1 plays a pivotal role in oxidative stress and the inflammatory response. However, its relationship with traumatic sepsis remains unknown. In a study aimed to identify whether VAN1 could be used as a biomarker for traumatic sepsis, scientists found there is a significant relationship between plasma VAN1 and sepsis in both the internal test cohort and the external validation cohort. These results contribute to the body of evidence supporting the use of plasma VAN1 in the early prediction of traumatic sepsis.
Learn more about that study here.
Eagle Biosciences offers a comprehensive Vanin-1 ELISA for urine samples.
Vanin-1 ELISA Assay Highlights
- Optimized for human urine samples
- Highly SPECIFIC and DEFINED characterized antibodies
- RELIABLE – rigorously validated
- QUICK one-step ELISA
We also provide a Vanin-1 Mouse/Rat ELISA Assay Kit that has been validated for mouse or rat serum, plasma, or urine samples.
If you have any questions about this product or our other offerings, contact us here.